Registration Dossier
Registration Dossier
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EC number: - | CAS number: 2495-39-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no GLP, 30 min. incubation time
- Qualifier:
- according to guideline
- Guideline:
- ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- - Name and location of sewage treatment plant where inoculum was collected: municipal WWTP Deidesheim (sampled 6.6.1989)
- Initial biomass concentration: 4.7 g/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 30 min
- Nominal and measured concentrations:
- Nominal: 1000 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Key result
- Duration:
- 30 min
- Dose descriptor:
- EC0
- Effect conc.:
- >= 260 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Duration:
- 30 min
- Dose descriptor:
- EC0
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- At 1000 mg/l stimulation of the respiration (5%) was observed.
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: EC50 = 15 mg/L - Validity criteria fulfilled:
- not specified
Reference
Description of key information
EC0(30 min) >= 260 mg/L (nominal, active ingredient) for activated sludge (ISO8192, part B)
Key value for chemical safety assessment
Additional information
One study investigating the toxicity of the test substance to aquatic microorganisms is available. The study was performed according to ISO guideline 8192 using activated sludge as inoculum (Wonner 1989).
1000 mg product/L (= 260 mg a.i./L) were tested in a limit test. After an incubation time of 30 minutes, no respiration inhibition was obsereved in the treatment compared to the control. Thus, the 30 min-EC0 is determined to be >= 260 mg a.i./L based on nominal concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
