Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 906-256-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
There is no mutagenicity data available on the multiconstituent substance, but data is available on the main components from which it can be concluded that mutagenicity/genotoxicity are not important characteristics.
Data on individual components:
Ethylene glycol (ethan-1,2-diol) :
BASF (2013) reported a negative result with and without metabolic activation, when tested ethylene glycol in a bacterial reverse mutation test. Concentrations of up to 5000 ug/plate were used. BRRC (1985) reported an in vitro mammalian chromosome aberration test using Chinese hamster ovary cells. Concentrations ranged from 10 - 100 mg/ml. Results obtained with and without metabolic activation indicated that ethylene glycol did not produce significant increases in chromosome aberrations in comparison to values of control cultures. Ethylene glycol was not considered to be a clastogenic agent under the conditions of this in vitro test system. McGregor et al. (1991) found a negative result with and without metabolic activation, when ethylene glycol was tested in a mammalian cell gene mutation assay. Mouse lymphoma cells were used; concentrations were up to 5000 ug/ml.
Diethylene glycol (2,2’-oxydiethanol
BASF (2013) reported a negative Ames test result according to EU Method B.10. Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 and and E Coli WP2 uvra were used with and without metabolic activation. Concentrations ranged up to 5000 ug/plate. Diethylene glycol was neither genotoxic nor cytotoxic to CHO cells when tested with and without metabolic activation in an in vitro mammalian chromosome aberration test with a concentration of 50 mg/ml (Union Carbide, 1984). A negative result with and without metabolic activation was found in a sister chromatid exchange assay using CHO cells. Concentrations used ranged from 30 - 50 mg/ml (Union Carbide, 1984).
Triethylene glycol (2,2’-(ethylenedioxy)diethanol):
Triethylene glycol was tested in an Ames test (BASF, 2012). Four Salmonalla strains and E coli WP" uvra were used, concentrations ranged up to 5000ug/plate. This test showed a negative result with and without metabolic activation. In an in vitro mammalian chromosome aberration test with Chinese hamster ovary cells, trieethylene glycol did not produce increases in chromosome aberrations in comparison to values of control cultures with and without metabolic activation.. No evidence of clastogenic or cytotoxic effects were observed. Concentrations tested were 35, 42 and 50 mg/l (BRRC, 1986).
Short description of key information:
Bacterial reversion mutation assays: MEG, DEG, TEG: negative
Chromosome abberation in vitro studies: MEG, DEG, TEG: negative
Mouse lymphoma studies: MEG: negative
Sister Chromatid exchange assays: DEG, TEG: negative.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Classification for mutagenicity/genotoxicity is not warranted based on the available data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.