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Reaction mass of Sodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][1-[(2-hydroxy-5-nitrophenyl)azo]-,Sodium bis[1-[(2-hydroxy-5-nitrophenyl)azo]naphthalen-2-olato(2-)]cobaltate(1-)and Sodium bis[2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)]cobaltate(1-)
EC number: 916-867-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: A study according OECD TG 423 was performed and the acute oral LD50 was calculated to be > 375 < 2500 mg/ kg bw in female Wistar rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Quality of whole database:
- OECD TG 423
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral
In an acute oral toxicity study performed according to OECD TG 423 (Acute Toxic Class Method), doses of 2500 and 375 mg/kg bw of the test item preparations in corn oil were given by gavage to three test groups of three fasted Wistar rats each (2500 mg/kg bw in 3 females, 375 mg/kg bw in 6 females).
Mortality of two animals was observed in the 2500 mg/kg bw group. Furthermore, the following test substance-related clinical observations were recorded: impaired general state in all animals, dyspnoea in all animals, piloerection in all animals, cowering position in all animals, staggering in two animals, diarrhea in all animals, exsiccosis in one animal, red-brown discolored feces in all animals, body weight reduction in all animals and smeared fur with feces in one animal.
In one animal that died dark discoloration of the liver was detected. Due to advanced putrefaction no macroscopic pathological findings could be determined in the second animal.
In both test groups of the 375 mg/kg bw dose, no mortality occurred. The following clinical signs were recorded for the first test group: impaired general state in two animals, piloerection in two animals, smeared fur with feces in one animal, red-brown discolored feces in one animal and black discolored feces in three animals.
In the second test group of the 375 mg/kg bw group the following clinical sings were detected: impaired general state in one animal and piloerection in one animal.
There were no macroscopic pathological findings in the surviving animals of the 375 mg/kg bw group sacrificed at the end of the observation period.
The single surviving animal of the 2500 mg/kg bw test group lost body weight within the first 3 days after administration but gained weight in a normal range for the remainder of the observation period. In both 375 mg/kg bw test groups the body weight increased normally during the study period with one exception in the first 375 mg/kg bw test group. In this animal the body weight increased during the first observation week but stagnated during the second week. This effect is observed at times in the rat strain used, because in the required age range the female animals have already reached the phase of slow growth.
The acute oral LD50 was calculated to be > 375 < 2500 mg/kg bw (Bioassay, 2017).
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data is reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is considered to be classified for acute oral toxicity Cat.4 (H302: "Harmful if swallowed") under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.
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