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Diss Factsheets
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EC number: 916-331-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The effects of Cyclabute on mortality and reproduction of Daphnia magna were determined in a semi-static test with an exposure period of 21 days. The 21 day NOEC and EC10 were determined to be 0.462 and 0.126 mg test item/L for reproduction. Usually, the EC10 represents the key value for reproduction studies. In contradiction to the usual evaluation in this study the NOEC is presented as the key value. With regard that in this study no clear dose response was found at the lower test item concentrations, the statistical output showed the EC10–value to be lower than the NOEC; At the lowest test item concentration of 0.0089 mg/L an inhibition of 11.9 % was observed, compared to an inhibition of -1.3 % at the next higher test item level of 0.0307 mg/L. At the test item concentration of 0.164 mg/L the inhibition increased to 9.7 %. Even at the test item concentration of 0.462 mg/L the inhibition of 13 % in reproduction is only slightly above the inhibition observed at the lowest test item concentration. In sum this affects the statistical evaluation of the EC10. In addition, the two lowest test item concentrations had to be averaged with the LoD according to the test guideline, which also affects the calculation of the EC10 towards a less realistic value compared to the reported NOEC. In contrast to the EC10 the NOEC is based on realistic averaged measured concentrations between two water renewals (without being averaged with the LoD). Therefore, we conclude for this study based on the summarized results that the NOEC is a better key value than the EC10.
The 21 day EC10 and NOEC were determined to be 0.126 and 0.462 mg test item/L for reproduction. For mortality of the adult test animals the EC10 and NOEC were determined to be 1.599 and ≥ 1.83 mg test item/L. The EC50 for reproduction was 3.30 mg test item/L (extrapolated value) and >1.830 mg test item/L for mortality.
The initial concentrations and the maintenance of the exposure concentrations during the test were verified in the analytical part. All reported results refer to time weighted average concentrations, since the test item concentrations were not within ± 20% of the nominal or measured initial concentrations during the test.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.46 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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