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EC number: 619-020-1 | CAS number: 94361-06-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Dec 1998 to 30 Dec 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT157.1
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 93 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 250 mg/L
- Incubation duration:
- 72 h
- Temp.:
- 22 °C
- pH:
- 7.1
- Conclusions:
- The water solubility of pure test substance at 22 °C is 108 ± 8 mg/L at pH 4.1, 93 ± 18 mg/L at pH 7.1 and, 109 ± 4 mg/L at pH 10.0.
- Executive summary:
The water solubility of the pure test substance has been determined using the flask method in accordance with CIPAC MT157.1 and in compliance with GLP criteria. At 22 °C the water solubility was 108 ± 8 mg/L at pH 4.1, 93 ± 18 mg/L at pH 7.1 and, 109 ± 4 mg/L at pH 10.0.
Reference
RESULTS
Six solutions containing known amounts of the cyproconazole reference substance and p-chlorobenzophenone as internal standard were used as calibration solutions. These solutions and the diluted test solutions, were injected into the HPLC. The peak areas were integrated and the content of the individual diastereomers A and B in the sample solutions were calculated as mg in 10 mL test solution (see Table 1 in “Any other information on results incl. tables”).
The sum of the diastereomers A and B gives the concentration of test substance, calculated as mg of the 100 % pure material in 10 mL test solution. Based on these figures, the solubility of test substance and the individual diastereomers were calculated in ppm or mg/1000 mL aqueous solution.
SOLUBILITY
Solubility at pH 4.1
Test substance: 108 ± 8 ppm
diastereomer A 51 ± 3 ppm
diastereomer B: 57 ± 6 ppm
Solubility at pH 7.1
Test substance: 93 ± 18 ppm
diastereomer A 46 ± 9 ppm
diastereomer B: 47 ± 9 ppm
Solubility at pH 10
Test substance: 109 ± 4 ppm
diastereomer A 54 ± 2 ppm
diastereomer B: 55 ± 3 ppm
INTERPRETATION
The calibration curve which was obtained from the calibration solutions at the various concentration levels was found to be very accurate, the relative standard deviation being less than 1 %. The results calculated for the samples exhibit somewhat bigger deviations. The range of the relative standard deviations is between 4 and 10 % in the sample solutions at pH 4 and 10, but about 20 % in the solutions at pH 7. However, no significant trend in increased water solubility could be observed during prolonged equilibration periods. This indicates that the equilibrium plateau was reached even after short investigation period and that substance was not degraded during the whole experiment. The ratio of the diastereomers A to B is about 49 : 51 in the solid test material, whereas the ratio in the saturated aqueous solutions is found to be in the range of 47 : 53 at pH 4, 49 : 51 at pH 7 and 50 : 50 at pH 10. Therefore, no preference of one of the diastereomer over the other could be observed during the solubility step.
Table 1: Analytical results
Sample No. | Time in hours at | pH | mg substance/10 mL tests solution | |||
30 °C | 22.0 °C | diaster A | diaster B | a.i. | ||
Buffer solution pH 4.0 | ||||||
4/24/1 | 24 | 65 | 4.1 | 0.51 | 0.63 | 1.14 |
4/24/2 | 0.50 | 0.62 | 1.12 | |||
4/48/1 | 48 | 65 | 4.1 | 0.45 | 0.47 | 0.92 |
4/48/2 | 0.54 | 0.56 | 1.10 | |||
4/72/1 | 72 | 65 | 4.1 | 0.54 | 0.59 | 1.13 |
4/72/2 | 0.52 | 0.58 | 1.1 0 | |||
Average | 0.51 ± 0.03 | 0.57 ± 0.06 | 1.08 ± 0.08 | |||
Buffer solution pH 7.0 | ||||||
7/24/1 | 24 | 65 | 7.1 | 0.31 | 0.33 | 0.64 |
7/24/2 | 0.49 | 0.51 | 1.00 | |||
7/48/1 | 48 | 65 | 7.1 | 0.54 | 0.53 | 1.07 |
7/48/2 | 0.51 | 0.50 | 1.01 | |||
7/72/1 | 72 | 65 | 7.1 | 0.54 | 0.54 | 1 08 |
7/72/2 | 0.39 | 0.39 | 0!;.78 | |||
Average | 0.46 ± 0.09 | 0.47 ± 0.09 | 0.93 ± 0.18 | |||
Buffer solution pH 10.0 | ||||||
10/24/1 | 24 | 65 | 10 | 0.53 | 0.55 | 1.08 |
10/24/2 | 0.51 | 0.52 | 1.03 | |||
10/48/1 | 48 | 65 | 9.9 | 0.53 | 0.53 | 1.06 |
10/48/2 | 0.56 | 0.55 | 1.11 | |||
10/72/1 | 72 | 65 | 10 | 0.54 | 0.58 | 1.1 2 |
10/72/2 | 0.55 | 0.59 | 1.14 | |||
Average | 0.54 ± 0.02 | 0.55 ± 0.03 | 1.09 ± 0.04 |
Description of key information
93 mg/L in water at 22 °C at pH 7.1, flask method, CIPAC MT157.1, Wisson 19897.
Key value for chemical safety assessment
- Water solubility:
- 93 mg/L
- at the temperature of:
- 22 °C
Additional information
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