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EC number: 500-086-4 | CAS number: 35238-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to O.E.C.D. Testing Guideline No. 202 with GLP compliance.
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-Acetone, polymer with phenol
- EC Number:
- 500-086-4
- EC Name:
- 2-Acetone, polymer with phenol
- Cas Number:
- 35238-34-7
- Molecular formula:
- (C6H6O.C3H6O)x
- IUPAC Name:
- 2-Propanone, polymer with phenol
- Reference substance name:
- 2-Acetone polymer with phenol
- IUPAC Name:
- 2-Acetone polymer with phenol
- Reference substance name:
- BPA-Tars
- IUPAC Name:
- BPA-Tars
- Details on test material:
- As per IUCLID5 Sections 1.1. - 1.4.
Constituent 1
Constituent 2
Constituent 3
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were collected once for measurment of BPA-Tars at the termination of exposure, 48 hr.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Reconstituted water (so-called 'M4 medium') was used for the preparation of stock and test substance solutions. The appropriate amount of BPA-Tars was added to 1 litre of dilution water followed by treated for one hour in an ultrasonic bath and stirred for 24 h on magnetic stirrers. The nominal concentrations were: 2.5, 5, 10, 20 and 40 mg/L.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Source : Strain of Bundesgesundheitsamt Berlin
Maintenance and Acclimatisation : A population of parthenogenetic females of synchronized age structure has been maintained for more than 15 years in the test facility under constant temperature conditions (20 +/- 1 °C) at a 16 : 8 hour light-dark photoperiod (illumination: < 1000 lux). The culture water (so-called 'M4 medium') was partly renewed once a week. The Daphnia were exclusively fed with unicellular green algae (Desmodesmus subspicatus) 'ad libitum'. Mortalities of parent Daphnia during the culture period were recorded daily in a semi-quantitative way. The neonates were separated from their parent Daphnia by filtration prior to the acute test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- The total hardness of the dilution water, measured at test start, was 14.8°dH (= 264 mg/L CaCO3).
- Test temperature:
- 19.4 to 19.7 °C
- pH:
- 8.0
- Dissolved oxygen:
- > 3 mg/L
- Salinity:
- No data, freshwater
- Nominal and measured concentrations:
- 0 (control) and 2.5, 5, 10, 20 and 40 mg/L
- Details on test conditions:
- 50 mL glass beakers covered with watch glasses holding 10 neonate Daphnids and 20 mL of test medium were used for exposure. There were 5 test concentrations plus 1 control and 2 replicates per concentration/control. There was no feeding of the Daphnids during the exposure period. Exposure was under a static system for 48 hr without areation.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 9.81 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.27 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The results are expressed in terms of initial concentrations. Effective concentrations ranged from 36.7 – 75.2% of nominal values at 0 hours, and from 51.6 – 73.6% of nominal values at 48 hours, respectively. Based on initial concentrations measured concentrations ranged from 94.3 – 99.1% of initial values after 24, 48 hours of exposure respectively. Immobilization of the Daphnids was observed at nominal test substance concentrations of 20 mg/L and higher. Immobilization was 100% at 24 hr at the high nominal dose level of 40 mg/L.
- Reported statistics and error estimates:
- Probit analysis was ised to estimate the EC50 values.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated EC50 values for BPA-Tars in this study were 9.8 mg/L at 24 hr of exposure and 8.3 mg/L at 48 hr. These data suggest that Classification and Labeling as Toxic to aquatic organisms is necessary.
- Executive summary:
2 -Acetone polymer with phenol (BPA-Tars) was evaluated for acute toxicity to Daphnia magna by an O.E.C.D. No. 202 Test Guideline study with GLP compliance. The estimated EC50 values for BPA-Tars in this study were 9.8 mg/L at 24 hr of exposure and 8.3 mg/L at 48 hr. These data suggest that Classification and Labeling of BPA-Tars as Toxic to aquatic organisms is necessary.
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