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EC number: 500-086-4 | CAS number: 35238-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: the study was conducted according to O.E.C.D. Testing Guideline No. 301 F with GLP compliance including test substance characterization.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4,4'-isopropylidenediphenol
- EC Number:
- 201-245-8
- EC Name:
- 4,4'-isopropylidenediphenol
- Cas Number:
- 80-05-7
- Molecular formula:
- C15H16O2
- IUPAC Name:
- 2,2-bis(4-hydroxyphenyl)propane
- Reference substance name:
- 4,4’-isopropylidenediphenol
- IUPAC Name:
- 4,4’-isopropylidenediphenol
- Reference substance name:
- Phenol, 4,4’-(1-methylethylidene)bis-
- IUPAC Name:
- Phenol, 4,4’-(1-methylethylidene)bis-
- Reference substance name:
- Bisphenol A
- IUPAC Name:
- Bisphenol A
- Details on test material:
- As per IUCLID5 Sections 1.1. -1.4. for Bisphenol A.
Constituent 1
Constituent 2
Constituent 3
Constituent 4
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
As per IUCLID5 Sections 1.1. -1.4. for Bisphenol A.
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Activated sludge mixed liquor was obtained from the City of Midland Wastewater Treatment Pland (Midland, Michigan)
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 7 - 25 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- and CO2 production.
- Details on study design:
- Duplicate reaction flasks contained 30 mg/L activated sludge in defined mineral salts medium. The concentrations of Bisphenol a were 7 and 25 mg/L. The reaction flasks were incubated in darkness in a circulated air incubator with continous stirring at approximately 200 rom at 22.5 +/- 0.2 degrees C. Sodium benzoate at 100 mg/L was the positive control. Duplicate inoculum blanks (mineral salts medium only) and toxicity controls were also established.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 100 mg/L
Results and discussion
- Preliminary study:
- An initial study was conducted at a temperature of 27.1 +/- 0.6 degrees C. This elevated incubation temperature had little or no impact upon biodegradation kinetics.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- at 25 mg/L BPA.
- Value:
- ca. 81
- Sampling time:
- 28 d
- Remarks on result:
- other: Levels of biodegradation were similar for 7 mg/L Bisphenol A.
- Details on results:
- After an initial lag period of 4.7 to 6.1 days, a 60% biodegradation of Bisphenol A was achieved within 5 to 7 days of contact time. The biodegradation of 7 mg/L Bisphenol A ranged from 74.7 to 93.5% after 28 days. The biodegradation of 25 mg/L of Bisphenol A ranged from 75.9 to 93.5 % after 28 days of contact time.
BOD5 / COD results
- Results with reference substance:
- The biodegradation of sodium benzoate was 75.8 to 99.5% complete at 28 days and required 2.1 to 2.5 days to react 60% biodegradation.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Bisphenol A, a structural analog of 2-Acetone polymer with phenol (BPA-Tars) was "readily biodegradable" reaching a level of 60% biodegradation within a window of 5 to 7 days contact time. It is anticipated that BPA-Tars would achieve a similar level of biodegradation under the same experimental conditions.
- Executive summary:
A structural analog of BPA-Tars, Bisphenol A was assessed for ready biodegradability by an O.E.C.D. 301 F Testing Guideline study conducted according to the GLP regulations. Bisphenol A, was "readily biodegradable" reaching a level of 60% biodegradation within a window of 5 to 7 days contact time. It is anticipated that BPA-Tars would achieve a similar level of biodegradation under the same experimental conditions.
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