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Diss Factsheets
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EC number: 439-070-6 | CAS number: 125005-87-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 3 000 mg/kg bw/day
Additional information
Rats exposed to gellan gum at 5% in diet consumed the test diet at rates which declined over 10 weeks of treatment but were generally markedly above 3g test substance/kg/day:
- P generation males 6.0-3.0 g/kg/day, females 4.2-4.1 g/kg/day
- F1 generation males 6.5-2.8 g/kg/day, females 6.7-3.5 g/kg/day.
These high intakes had no detectable adverse effect on fertility (or development). It is reasonable to assume that Diutan, a biogum closely similar to gellan gum, would show a similar absence of toxicity to reproduction.
Short description of key information:
The close chemical analogue gellan gum has been tested for fertility/reproductive toxicity in a 2-generation rat feeding study. Exposure at levels up to 5% in diet (corresponding to intake in excess of 3g/kg/day in the highest exposure group) produced no evidence of treatment-related adverse effect on fertility or other reproductive parameters.
Effects on developmental toxicity
Description of key information
The close chemical analogue gellan gum has been tested for developmental toxicity in a rat teratology study. Exposure at levels up to 5% in diet (corresponding to intake of approximately 3.9g/kg/day in the highest exposure group) produced no evidence of maternal toxicity, embryo/foetal toxicity or developmental toxicity.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 3 900 mg/kg bw/day
Additional information
Pregnant female rats exposed during the period of organogenesis to gellan gum at 5% in diet consumed the test diet at rates which corresponded to a mean daily intake of approximately 3.9 g test substance/kg/day. No significant maternal toxicity or adverse effects on indices of embryo/foetal toxicity or developmental parameters were seen.
It is reasonable to assume that Diutan, a biogum closely similar to gellan gum, would show a similar absence of developmental toxicity.
Justification for classification or non-classification
Reliable test data for a very close chemical analogue have demonstrated an absence of reproductive toxicity. No classification of Diutan for reproductive toxicity is therefore appropriate.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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