Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 281-161-6 | CAS number: 83877-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as substance is hydrolytically unstable. Based on the rapid hydrolysis, and the ready biodegradability and low aquatic toxicity of the known decomposition products, this substance can be considered as readily degradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Biodegradability testing of this substance is not scientifically justified as it is hydrolytically unstable. When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than 2 -methylpropanol, ethyl acetoacetate and hydrated titanium dioxides (half-life less than 10 minutes, Brekelmans 2013). In addition, biodegradability testing is not necessary as all the decomposition products have been identified.
The organic degradation products (2 -methylpropanol and ethyl acetoacetate) are also readily biodegradable. TiO2 is inorganic and insoluble and therefore not relevant to be considered for this endpoint.
Several studies have been conducted to assess the biodegradation of 2 -methylpropanol. Biodegradation of 2-methylpropanol in 20-d BOD test was 72 % of ThOD and 74 % at 28-d OECD 301 D closed bottle test (Waggy et al. 1994).Based on the study by Price et al. (1974), 20-d biodegradation of 2-methylpropanol using non-adapted settled domestic wastewater was 72 % in freshwater at nominal test concentrations of 3, 7 and 10 mg/l. According to the study by Dias and Alexander (1971), a 30-day BOD test at 30°C reported 42 % bio-oxidation by day 2, 61 % by day 5, 75 % by day 10 and 55 % by day 30 for 2-methyl-1-propanol. Values were corrected for oxygen consumption in bottles with no test substance present, which accounted for the lower rate on day 30. Aerobic biodegradation in adapted sludge was measured to be 44 % of theoretical oxygen required for complete oxidation of 500 ppm test solution after 23 hours (McKinney and Jeris 1955). Aerobic biodegradation in unadapted sludge was found to be 10.4 % of ThOD after 24 hours (Gerhold and Malaney 1966). All the studies show the 2 -methylpropanol is readily biodegradable.
Ethyl acetoacetate is also classified as readily biodegradable based on the closed bottle test results (European Chemicals Bureau 2002). The biodegradation after 28-d was 66 %. After 7 days , 65 % ethyl acetoacetate was degraded and 10-day window was fulfilled.
Based on the information on aquatic toxicity and biodegradation of the decomposition products, and the rapid hydrolysis of the target substance, the abiotic degradation can be used to demonstrate fast degradation of this substance for the purposes of C&L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.