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EC number: 277-633-6 | CAS number: 73912-21-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING (see supporting expert statement)
The feasibility of a hydrolysis study with the test item was assessed based on the performed tests, i.e. water solubility and analytics. As a consequence of the very low water solubility of the test item a solubility test was performed using different solvents to determine the appropriate solvent for the preparation of the stock solution and the sample solution. In a second step, the analytical behaviour of the test item was investigated in order to obtain an analytical method for the analysis of the sample solution with an appropriate sensitivity considering the potential amount of the test item in the aqueous test solution.
The results of the experiments indicated that reproducible analytical results could only be obtained in absence of water. This could be traced back either to the very low solubility or to the stability of the test item in water.
A study to investigate the hydrolytic properties of the test item cannot be performed. Regarding the estimated water solubility of 1.171*10exp(-8) mg/L (at 25°C) no analytical method with the appropriate sensitivity is available or could be developed. Moreover, it can be assumed that only a negligible portion of the test item will enter the aquatic environment as soluble substance and hence the impact on the aquatic environment was considered to be of low extent.
Hence, it can be concluded that hydrolysis testing is neither technically feasible nor required. - Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Endpoint:
- hydrolysis
- Type of information:
- other: Expert Statement supported by experimental results
- Adequacy of study:
- supporting study
- Study period:
- until 2016-11-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Expert statement supported well-documented experimental results
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Remarks:
- Waiver for which the present entry serves as supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- Expert Statement displaying why a study according to OECD 111 cannot be performed
- Deviations:
- not applicable
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At 4°C ± 4°C , in the dark
- Safety Precautions: Routine safety and hygienic procedures - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Solubility and analytical investigations were performed in a scientifically reasonable and well documented manner in order to assess the possibility / feasibility to perform a hydrolysis study according to OECD 111 as stipulated under REACH for registrations > 10 tpa. The results of the experiments indicated that reproducible analytical results could only be obtained in absence of water. This could be traced back either to the very low solubility or to the stability of the test item in water.
A study to investigate the hydrolytic properties of the test item cannot be performed. Regarding the estimated water solubility of 1.171*10-8 mg/L (at 25°C) no analytical method with the appropriate sensitivity is available or could be developed. Moreover, it can be assumed that only a negligible portion of the test item will enter the aquatic environment as soluble substance and hence the impact on the aquatic environment was considered to be of low extent.
Hence, it can be concluded that hydrolysis testing is neither technically feasible nor required. - Executive summary:
The feasibility of a hydrolysis study with the test item was assessed based on the performed tests. As a consequence of the very low water solubility of the test item a solubility test was performed using different solvents to determine the appropriate solvent for the preparation of the stock solution and the sample solution. In a second step, the analytical behaviour of the test item was investigated in order to obtain an analytical method for the analysis of the sample solution with an appropriate sensitivity considering the potential amount of the test item in the aqueous test solution.
The results of the experiments indicated that reproducible analytical results could only be obtained in absence of water. This could be traced back either to the very low solubility or to the stability of the test item in water.
A study to investigate the hydrolytic properties of the test item cannot be performed. Regarding the estimated water solubility of 1.171*10-8 mg/L (at 25°C) no analytical method with the appropriate sensitivity is available or could be developed. Moreover, it can be assumed that only a negligible portion of the test item will enter the aquatic environment as soluble substance and hence the impact on the aquatic environment was considered to be of low extent.
Hence, it can be concluded that hydrolysis testing is neither technically feasible nor required.
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2015-02-18 - 2015-03-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- read-across source
- Remarks:
- Waiver for which the present entry serves as supporting information
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In preparation for a hydrolysis study to be conducted under GLP, a solvent screening to find accceptable solvent conditions was conducted. Method: NMR measurement
- GLP compliance:
- not specified
- Remarks:
- Available Information: QM-system: DIN EN ISO/IEC 17025 / DAkkS Deutsche Akkreditierungsstelle
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- See "any other information on materials and methods"
- Buffers:
- none
- Details on test conditions:
- See "any other information on materials and methods"
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- Result
In our experiments no suitable solvent system for studying the hydrolysis by in-situ NMR was found. Even at very low concentrations such as 0.033% (w/w) a precipitate was formed. Furthermore the sensitivity of the 31P-NMR measurement is not high enough to observe any resonances.
Our result is in good agreement with the statement in the product data sheet of the customer in which the product is described as insoluble in water. - Validity criteria fulfilled:
- not applicable
- Conclusions:
- The present screening study was conducted in order to find acceptable solvent conditions in preparation for a hydrolysis study to be conducted under GLP. The study was well designed and sufficiently documented, so the results can be considered as sufficiently reliable to assess the feasibility of a hydrolysis study. No suitable solvent system for studying the hydrolysis by in-situ NMR was found. Even at very low concentrations such as 0.033% (w/w) a precipitate was formed. Furthermore the sensitivity of the 31P-NMR measurement is not high enough to observe any resonances. Hence, a hydrolysis study is not considered to be technically feasible.
- Executive summary:
In preparation for a hydrolysis study to be conducted under GLP, a solvent screening to find acceptable solvent conditions was conducted. No suitable solvent system for monitoring the hydrolysis of 4,8-dicyclohexyl-6-hydroxy-2,10-dimethyl-12H-dibenzo[d,g][1,3,2]dioxaphosphocin was found. A hydrolysis study is not considered to be technically feasible.
Referenceopen allclose all
Description of key information
Hydrolysis testing is neither technically feasible nor required. A study to investigate the hydrolytic properties of the test item cannot be performed. Regarding the estimated water solubility of 1.171*10exp(-8) mg/L (at 25°C) no analytical method with the appropriate sensitivity is available or could be developed. Moreover, it can be assumed that only a negligible portion of the test item will enter the aquatic environment as soluble substance and hence the impact on the aquatic environment was considered to be of low extent. Also, no suitable solvent for hydrolysis study (in situ NMR) of 4,8-dicyclohexyl-6-hydroxy-2,10-dimethyl-12H-dibenzo[d,g][1,3,2]dioxaphosphocin was found.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.