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EC number: 276-516-7 | CAS number: 72243-90-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- January 22 to March 22, 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- The read across approach is detailed into the document attached into the "information panel" of the Aquatic Toxicity endpoint summary.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Details on test solutions:
- The substance was direct dispersed in water.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain: laboratory culture originating from a strain supplied by I.R.CH.A., France.
- Breeding: testing laboratoyr, cultures maintained at 21°C in polypropylene vessels containing two litres of dechlorinated and aged tap water. Culture conditions ensure that reproduction is by parthenogenesis.
- Age of parental stock: gravid adults were isolated 24 hours prior to initiation of the test. Young daphnids produced overnight were used for testing.
- Feed: cultures were fed daily with a suspension of mixed algae (predominantly Chlorella spp.). - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- Start: 21 °C
End: 21 °C - pH:
- Start: 7.4
End: 7.2 - Dissolved oxygen:
- Start: 8.7 mg O2/l
Start: 8.1 mg O2/l - Nominal and measured concentrations:
- 5.0, 9.0, 16, 28, 50, 90, 160, 280 and 500 mg active ingredient/l
- Details on test conditions:
- TEST SYSTEM
- Daphnia loading: according to test protocol.
TEST MEDIUM / WATER PARAMETERS
- Water quality characteristics: according to test protocol. - Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 140 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Details on results:
- EC0 (48h): 16 mg a.i./l (nominal)
EC100 (48h): 500 mg a.i./l (nominal) - Results with reference substance (positive control):
- EC50 (24h): 1.5 mg/l
- Conclusions:
- EC50 (48h): 140 mg a.i./l (nominal)
- Executive summary:
The acute toxicity of substance to Daphnia magna was investigated under static exposure conditions over a period of 48 hours, according to the OECD testing guideline. The following concentrations were tested: 5.0, 9.0, 16, 28, 50, 90, 160, 280 and 500 mg active ingredient/l.
Potassium dichromate was also tested as reference substance.
The maximum concentration causing no immobilization after 48 hours was 16 mg a.i./l (nominal); on the contrary, at the concentration of 500 mg a.i./l all the test organisms resulted to be immobilized. The EC50 at 48 hours was determied to be 140 mg a.i./l.
Conclusion
EC50 (48h): 140 mg a.i./l (nominal)
Reference
Cumulative immobilisation of daphnids (%) test item
Concentration (mg a.i./l) | 24 hrs | 48 hrs |
Control | 0 | 0 |
Test item 5.0 | 0 | 0 |
Test item 9.0 | 0 | 0 |
Test item 16 | 0 | 0 |
Test item 28 | 5 | 5 |
Test item 50 | 5 | 15 |
Test item 90 | 10 | 20 |
Test item 160 | 20 | 60 |
Test item 280 | 30 | 70 |
Test item 500 | 60 | 100 |
Immobilisation rate of daphnids (%) reference substance
Concentration (mg a.i./l) | 24 hrs | 48 hrs |
Control | 0 | 0 |
Reference substance 0.10 | 0 | 0 |
Reference substance 0.18 | 0 | 0 |
Reference substance 0.32 | 0 | 0 |
Reference substance 0.56 | 5 | 5 |
Reference substance 1.0 | 5 | 15 |
Reference substance 1.8 | 10 | 20 |
Reference substance 3.2 | 20 | 60 |
Reference substance 5.6 | 30 | 70 |
Reference substance 10 | 60 | 100 |
Description of key information
EC50 (48h): 140 mg a.i./l (nominal)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 140 mg/L
Additional information
There are no information about the short-term potential toxicity of Acid Violet 048 to acquatic invertebrates, thus the available information on the structural analogous Similar Substance 01 has been taken into consideration; the read across approach can be considered as appropriate and suitable to assess the property under investigation (details about the approach are reported into the document attached into the "information panel" of the Aquatic Toxicity endpoint summary).
The acute toxicity of Similar Substance 01 to Daphnia magna was investigated under static exposure conditions over a period of 48 hours, according to the OECD testing guideline 202. The maximum concentration causing no immobilization after 48 hours was 16 mg a.i./l (nominal); on the contrary, at the concentration of 500 mg a.i./l all the test organisms resulted to be immobilized. The EC50 at 48 hours was determied to be 140 mg a.i./l.
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