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EC number: 271-865-1 | CAS number: 68610-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 09, 2018 - June 11, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: isothermal thermogravimetry
- Specific details on test material used for the study:
- - Composition of test material: Sodium-2-ethylhexyliminomonopropionate and Sodium-2-ethylhexyliminodipropionate
- Analytical purity: >=98%
- Purity test date: 13 December 2017
- Lot/batch No.: WI6K21X06-FD2
- Expiration date of the lot/batch: 05 December 2018
- Appearance: White paste
- Storage: At room temperature - Key result
- Temp.:
- 20 °C
- Vapour pressure:
- < 0.002 Pa
- Remarks on result:
- other: 0.000011 mm Hg
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- < 0.004 Pa
- Remarks on result:
- other: 0.000030 mm Hg
- Conclusions:
- The isothermal TGA effusion method was applied for the determination of the vapour pressure of the test item. The vapour pressure of the test item (impurities excluded) at 20°C (293K) and 25°C (298K) was < 0.0015 Pa and < 0.004 Pa, respectively.
- Executive summary:
The vapour pressure of the test item was determined in a GLP-compliant study performed in accordance with EU A.4 Method and OECD Guideline No. 104, using the isothermal TGA effusion method. The vapour pressure of the test item (impurities excluded) was < 0.0015 Pa at 20°C and < 0.004 Pa at 25°C.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2012-08-27 --> 2012-09-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- effusion method: by loss of weight or by trapping vaporisate
- Temp.:
- 20 °C
- Vapour pressure:
- < 0.002 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- < 0.006 Pa
- Conclusions:
- The vapour pressure of the test substance was determined to <1.5 mPa at 20°C and <5.8 mPa at 25 °C.
- Executive summary:
The vapour pressure of the test substance was determined to <1.5 mPa at 20°C and <5.8 mPa at 25 °C.
Referenceopen allclose all
Weight loss was observed from the start of the study and was due to evaporation of impurities, including residual water. In the range of 30°C and 60°C, non-linear weight loss was observed and the results within this range were therefore not reliable for the determination of the vapour pressure. Since no reliable vapour pressure could be calculated from the results obtained in the range of 30°C and 60°C, the weight losses were compared with the results of naphthalene.Since the weight loss of the impurities was lower than the weight loss of the reference compound, the vapour pressure is considered to be lower than that of naphthalene. For information, the corresponding vapour pressure at 20°C and 25°C was < 7.6 Pa and < 12 Pa, respectively.
From 140°C upwards, reaction and/or decomposition was observed. Therefore weight loss was determined in the range of 100°C and 130°C. Within this range, non-linear weight loss was observed and the results within this range were therefore not reliable for the determination of the vapour pressure. Since no reliable vapour pressure could be calculated from the results obtained in the range of 100°C and 130°C, the weight losses were compared with the results of hexachlorobenzene. Since the weight loss of the test item was lower than the weight loss of the reference compound (except at 100°C), the vapour pressure of the test item is considered to be lower than that of hexachlorobenzene. The corresponding vapour pressure at 20°C and 25°C was < 0.0015 Pa and < 0.004 Pa, respectively.
Description of key information
The vapour pressure of 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) was determined in a GLP-compliant study performed in accordance with EU A.4 Method and OECD Guideline No. 104, using the isothermal TGA effusion method. The vapour pressure of the test item (impurities excluded) was < 0.0015 Pa at 20°C and < 0.004 Pa at 25°C.
Key value for chemical safety assessment
- Vapour pressure:
- 0.002 Pa
- at the temperature of:
- 20 °C
Additional information
The vapour pressure of 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) was determined in a GLP-compliant study performed in accordance with standard methods, without deviations (Volic, 2018). The study is considered as reliable (Klimisch 1) and was selected as a key study for the endpoint.
The endpoint study summary for 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) is linked to study record(s) on the substance itself but also to study record(s) on an analogue substance, a.k.a. Sodium 3-[(2-carboxyethyl)(2-ethylhexyl)amino]propanoate (CAS RN 94441-92-6 / EC 305-318-6). The latter is used as source substance to fill datagaps on 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) for particular endpoints pertaining to environmental fate, aquatic toxicity and human health toxicity. Several physico-chemical data are thus reported for the source substance (e.g.physical state, melting point, vapour pressure, surface tension, water solubility and n-octanol/water partition coefficient – identified as “supporting studies”) to support the read-across approach (cf. read-across justification document attached in "13 Assessment reports").
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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