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EC number: 270-877-4 | CAS number: 68479-98-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation
Three standard rabbit skin irritation studies, two with 24-hour occlusive exposures to abraded and intact skin with the undiluted test material, and one with a 4-hour occlusive exposure to intact skin with the undiluted test material, revealed different results (Jones 1983; Nelson et al. 1977; Heenehan 1977). In one of the 24-hour studies, the test material was classified as mildly irritating (Heenehan 1977), whereas in the other 24-hour study the test material was classified as non irritating (Nelson et al. 1977). Different laboratories performed these studies, but the same volume of the test material was used in each study, along with the same species/strain of animal, and application area for the test material. Therefore, one study cannot be readily dismissed over the other. The 4-hour study results were classified as non irritating (Jones 1983). Based on the foregoing information, it was concluded that the test material was slightly irritating.
Eye irritation
Two standard eye irritation studies were performed in rabbits using the undiluted test material (Heenehan 1977; Nelson et al. 1977). Irritation was noted in both studies. Heenehan (1977) utilized six animals, and Nelson et al. (1977) used nine animals. Of the 15 animals evaluated from both studies, one animal exhibited a response that persisted for up to 21 days. This finding was, however, considered spurious in light of the total number of animals evaluated.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The available irritation/corrosion studies indicate that the test material is slightly irritating to the skin and irritating to the eyes.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
The major criterion for classification as a Category 2 Irritant under GHS is the mean value of the scores for either erythema/eschar greater than or equal to 2.3, or oedema in at least two of three animals tested. Two of the three studies did not identify signs of skin irritation. In the one study that identified positive findings of skin irritation, the highest mean value for erythema/eschar formation at any time point was 2.0. Further, the oedema scores were either '1' (barely perceptible) or '0' (no oedema) at all time points. Therefore, the test substance does not meet the criteria for classification under GHS. See: Regulation (EC) No 1272/2008; See Official Journal of the European Union, (2008) Vol. L353, pp. 1-1355, at p. 88.
Two eye irritation studies reported positive findings. In one study, all of the effects were reversible. In the second study, corneal opacity was observed in one animal up to 21 days post treatment. This finding was, however, considered spurious because only one animal out of the fifteen used from both studies exibited such a response. Therefore, these data support the GHS classification criteria for substances that may cause Reversible effects on the eye (Category 2). See: Regulation (EC) No 1272/2008; See Official Journal of the European Union, (2008) Vol. L353, pp. 1-1355, at p. 93.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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