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Diss Factsheets
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EC number: 267-466-7 | CAS number: 67874-37-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25%, 50%, 100%
- No. of animals per dose:
- 3
- Statistics:
- EC3= 92.1%
- Parameter:
- EC3
- Value:
- 0.921
- Parameter:
- other: dpm/node
- Value:
- 942.43
- Test group / Remarks:
- 25% concentration
- Parameter:
- other: dpm/node
- Value:
- 1 746.07
- Test group / Remarks:
- 50% Concentration
- Parameter:
- other: dpm/node
- Value:
- 2 367.08
- Test group / Remarks:
- 100% concentration
- Parameter:
- SI
- Value:
- 1.25
- Test group / Remarks:
- 25% concentration
- Parameter:
- SI
- Value:
- 2.31
- Test group / Remarks:
- 50% concentration
- Parameter:
- SI
- Value:
- 3.13
- Test group / Remarks:
- 100% Concentration
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information weak
- Conclusions:
- Test substance was only postive (ratio >3) at a concentration of 100%, with an EC3 of 92.1%. While this substance is classifiable as a skin sensitiser based on these results, it would only be a weak sensitiser.
- Executive summary:
TiTDP was test using the LLNA assay at concentrations of 25%, 50%, and 100%. It was only just barely positive at the 100% concentration. The calculated EC3 value is 92.1%. The results suggest that while TiTDP will be classified as a skin sensitiser (since there is only one category for skin sensitisers) it is expected to be only a weak skin sensitiser.
Reference
Concentration |
dpm/node |
Test / Control Ratio |
Vehicle (acetone/olive oil 4:1) |
756.88 |
N/A |
25% |
942.43 |
1.25 |
50% |
1746.07 |
2.31 |
100% |
2367.08 |
3.13 |
EC3= 92.1% |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Local lymph node assay (LLNA) study (Harlan 2010) showed slight positive response at 100% concentration. EC3 value was determined to be 92.1%.
Migrated from Short description of key information:
Local lymph node assay (LLNA) study (Harlan 2010) showed slight positive response at 100% concentration. EC3 value was determined to be 92.1%.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Classified as a skin sensitizer based on the positive LLNA study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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