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EC number: 256-457-3 | CAS number: 49744-26-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 05, 2016 - December 08, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- column elution method
Test material
- Reference substance name:
- p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide
- EC Number:
- 250-205-6
- EC Name:
- p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide
- Cas Number:
- 30449-81-1
- Molecular formula:
- C23H29N5O3
- IUPAC Name:
- 4-[(5-cyano-2-hydroxy-1,4-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)diazenyl]-N-(2-ethylhexyl)benzamide
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- < 0.04 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 4.9
Any other information on results incl. tables
Individual results
Preliminary visual estimation of the water solubility
Three preliminary tests were carried out with specified amounts of the test item and 100 ml and 500 ml demineralized water, respectively. After each addition of an amount of water, the mixture was stirred for at least 24 hours, and visually checked for any undissolved particles
Table4: Results of the preliminary visual estimation of the water solubility
Amount of test item / mg |
Total volume of dist. water / ml |
Appearance of mixture |
11.3 |
100 |
not dissolved |
10.4 |
500 |
not dissolved |
4.0 |
500 |
not dissolved |
The preliminary visual experiments showed that the water solubility of the test item is < 10 mg/l. According to the preliminary visual estimation in the main test the water solubility was determined by the column elution method.
Column elution method
102.5 mg of the test item were dissolved in 100 ml acetone. For charging the columns in each case 25 ml of the test item solution was added to about 3 g of sea sand and the mixtures were shaken. The solvent was then removed under reduced pressure using a rotary evaporator (40 °C, approx. 20 mbar). The dry residues were placed into the columns of the test apparatus, which have afterwards been filled with water (test temperature: 20 °C; water pH at 24 °C: 5.5). After a swelling time of 2 h pumps were started to rinse the test item coated sand with demineralized water. At the end of the study it was confirmed that residual test item remained on the columns. The residual test item was eluted with 50 ml acetone.
As blank value the used demineralized water was tested. No signal was detected in the range of the retention time of the test item.
The concentration of the test item was quantified by HPLC.
Column 12.5 ml/h:
Rotation period of the fraction collector: 90 min per fraction
Duration of sampling: about 68 h (45 fractions)
Table5: Column elution method, column 12.5 ml/h
Fraction no. |
V / ml |
pH |
water solubility /µg/l |
28 |
17.0 |
4.9 |
< 33.6 |
29 |
17.0 |
4.9 |
< 33.6 |
30 |
17.0 |
4.9 |
< 33.6 |
31 |
17.0 |
4.9 |
< 33.6 |
32 |
17.0 |
4.8 |
< 33.6 |
The water solubility was found to be below the quantification limit of 33.6 µg/l.
Column 25.0 ml/h:
Rotation period of the fraction collector: 45 min per fraction
Duration of sampling: about 68h(90 fractions)
Table6: Column elution method, column 25.0 ml/h
Fraction no. |
V / ml |
pH |
water solubility /µg/l |
56 |
16.5 |
5.0 |
< 33.6 |
57 |
16.5 |
5.0 |
< 33.6 |
58 |
16.5 |
5.0 |
< 33.6 |
59 |
16.5 |
5.0 |
< 33.6 |
60 |
16.5 |
5.0 |
35.8 |
The water solubility was found to be below 40 µg/l.
In both columns the concentration of five consecutive fractions was constant within ± 30 %. No increasing or decreasing tendency was observed.
Coating check:
Table7: Coating check
|
Amount of test item used for coating / mg |
Measured concentration of test item in eluate / mg/l |
Amount of test item eluted / mg |
Column 12.5 ml/h |
27.5 |
0.188 / 0.189 |
15.7 |
Column 25.0 ml/h |
27.5 |
0.191 / 0.192 |
16.0 |
The coating check was successful. Enough test item remained on the columns.
Applicant's summary and conclusion
- Executive summary:
The water solubility cS of the test item Disperse Yellow 198 at a temperature of 20 °C was determined according to the column elution method. It was found to be below the quantification limit:
cS< 0.04 mg/l
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