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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991-12-12 to 1991-12-12
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: non GLP test with limited reporting but still valid for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
6-[methyl(phenylsulphonyl)amino]hexanoic acid
EC Number:
256-289-0
EC Name:
6-[methyl(phenylsulphonyl)amino]hexanoic acid
Cas Number:
46948-72-5
Molecular formula:
C13H19NO4S
IUPAC Name:
6-(N-methylbenzenesulfonamido)hexanoic acid
Details on test material:
Test substance was directly weighed into the test vessels
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
n.a.

Sampling and analysis

Analytical monitoring:
no
Details on sampling:
3h

Test solutions

Vehicle:
no
Details on test solutions:
Tes concentraions 500 and 1000 mg/L

Test organisms

Test organisms (species):
activated sludge, domestic
Details on inoculum:
Inoculum from municipal sewage treatment plant Frankfurt am Main - Sindlingen (Germany), 1600 mg/L dry weight, non acclimated to test substance

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
3 h
Post exposure observation period:
n.a.

Test conditions

Hardness:
n.a.
Test temperature:
20°C +/- 2
pH:
7.2 +/- 0.2
Dissolved oxygen:
saturated
Salinity:
n.a.
Nominal and measured concentrations:
nominal: 500 and 1000 mg/L
Details on test conditions:
n.a.
Reference substance (positive control):
yes
Remarks:
3,5-Dichlorophenol

Results and discussion

Effect concentrationsopen allclose all
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
NOEC
Effect conc.:
1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Details on results:
n.a.
Results with reference substance (positive control):
Validity criteria fulfilled, test system valid
Reported statistics and error estimates:
No effect at highest tested concentratiton

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The registration substance did not shown any inhibition of respiration in an OECD 209 test at the highest tested concentration of 1000 mg/L nominal.