2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate

Endpoint summary

Description of key information

Biodegradation in water

Biodegradability of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS no. 26672 -22 -0) is predicted using QSAR toolbox version 3.4 (2017) with logKow as the primary descriptor. Test substance undergoes 0.125% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be not readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0). If released in to the environment, 29.2% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0833%), indicates that 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate is not persistent in sediment.

 

Biodegradation in soil

The half-life period of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 70.7% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Bioaccumulation: aquatic / sediment

BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 2 -[(4 -amino-3 -methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0). The bioconcentration factor (BCF) of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate is not expected to bioaccumulate in the food chain.

Adsorption / desorption

KOCWIN model (v2.00) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the soil adsorption coefficient i.e Koc value of test chemical 2 -[(4 -amino-3 -methoxy phenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0). The soil adsorption coefficient i.e Koc value of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be 19.88 L/kg (log Koc=1.2983)  by means of MCI method (at 25 deg C). This Koc value indicates that the substance 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.

Additional information

Biodegradation in water

Various predicted data for the target compound 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672-22-0) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor, percentage biodegradability of test chemical2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate(CAS No. 26672-22-0) was estimated.Test substance undergoes 0.125% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphatewas estimated to be not readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate(CAS No. 26672-22-0) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphateis expected to be not readily biodegradable.

 

In a supporting weight of evidence study from peer reviewed journal (P. Pitter, 1976) for the read across chemical 5-aminonaphthalene-2-sulfonic acid (CAS no. 119-79-9), a batch test in an open system was conducted for 5 days for evaluating the biodegradability of read across 5-aminonaphthalene-2-sulfonic acid. Adapted activated sludge was used as a test inoculum obtained from a sewage plant is cultivated in a 1000ml volumetric cylinder. The mixture is aerated with pressure air. Every day 200 ml of the mixture is driven off so that the sludge age is 5 days. After driving off the 200ml of the mixture aeration is interrupted, and after sedimentation ca. 600mlof the liquid phase is driven off. The residue (200 ml of the thickened activated sludge) is diluted with tap water to the volume of ca.800 ml and 600 mg/l of starch or glucose, 600 mg/l of peptone, 25 ml of a phosphate buffer pH 7.2, and the solution of the tested compound are added. Then the mixture in the cylinder is made up to 1000ml with tap water and aerated for 23 h (the recirculation ratio is 0-25). After this period the procedure is repeated. Test chemical conc. used for the study was 200 mg/l based on COD. To 1000-1500ml of the biological medium such amount of the solution of the substance tested is added that the initial COD is 200 mg/l. Then such an amount of the adapted activated sludge, washed and thickened by sedimentation, is dosed to the medium that the concentration of the dry matter is 100 mg/l. Simultaneously, a blank test is prepared. The beaker is placed in a dark room with a roughly 3 constant temperature of 20±3°C on an electromagnetic stirrer and a pH of 7.2 for 120 hrs. The initial value of COD or organic carbon of the liquid phase are determined. Samples. filtered or centrifuged before analysis, are taken at suitable intervals. The decrease of the tested substance in the liquid phase is evaluated by determining COD or organic carbon. The results are compared with those of a blank test and standard compound decomposition. With the degree of degradation also the average specific rate of degradation is determined, expressed in terms of mg COD (or organic carbon) removed by a gramme of dry matter of the activated sludge per hour. The percentage degradation of 5-aminonaphthalene-2-sulfonic acid was determined to be 0% degradation by COD parameter in 5 days. Thus, based on percentage degradation, test substance 5 -aminonaphthalene-2 -sulfonic acid was considered to be not readily biodegradable in nature.

 

Another biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of read across substance 2-amino-5-methylbenzene sulfonic acid (CAS no. 88-44-8) (authoritative database J-CHECK, 2017 and secondary source OECD SIDS, 2003). The study was performed according to OECD Guide-line 301 C "Ready Biodegradability: Modified MITI Test (I)" under aerobic conditions. Aniline was used as a reference substance for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. Reference substance undergoes >40% and >60% degradation in 7 and 14 days, respectively. The percentage degradation of substance was determined to be 0 and <0% degradation by BOD, O2 consumption, TOC removal, Test mat. analysis and UV-Vis parameter in 14 days. Thus, based on percentage degradation, 2 -amino-5 -methylbenzene sulfonic acid is considered to be not readily biodegradable in nature.

 

For the read across chemical 4-Amino-1,1’-azobenzene-3,4'-disulfonic acid (CAS no. 101-50-8), biodegradation study of read across substance 4-Amino-1,1’-azobenzene-3,4'-disulfonic acid (acid yellow 9) was performed using 15 different Streptomyces spp. for 14 days (A. Paszcyzynski, et. al; 1991). The test was performed using 15 different Streptomyces spp as an inoculum. The test substance conc. used is 50 mg/l. Each Streptomyces spp. was grown in a cotton-plugged 250 ml flask containing 25 ml of the following medium: 0.2 M Tris buffer (pH 7.6) 100 ml, 1.0g vitamin-free Casamino acids, 100 µg thiamine, 100 µg biotin, 2 g D-glucose, 900 ml deionized water. Thiamine, biotin, and D-glucose were filter sterilized and added to the autoclaved medium. The dye was filter sterilized and added at 0.005% (w/v) to the autoclaved basal medium. Cultures were incubated at 37ᵒC for 14 days with shaking (200 rev min1). Three replicates for each strain grown in only the basal medium were incubated as well. Degradation of test substance was determined by spectrophotometrically and by using HPLC. Degradation of the test substance was confirmed by HPLC. A Hewlett-Packard HP 1090 Liquid Chromatograph equipped with a HP 40 diode array UV-VIS detector and automatic injector was used. The chromatograph was controlled by an HP 9000 series 300 computer which used HP 7995 A ChemStation software. A reverse phase column from Phenomenex (Rancho Palos Verdes, CA, type Spherex 5C 18 size 250 × 2.0 mm, s/no PP/6474A) was used. Each 15-min analysis used a solvent gradient of acetonitrile (solvent A) and 10mM DMS buffer pH 4.5 (solvent B), with the following conditions: 0-5 min, 100% A; 5-12 min, 25% A, 75% B; 12-15 min, 100% B; post time 2 min, injection volume 10µl. Absorption was measured at 250, 325, 350, 400 and 450 nm, and spectra were collected automatically by the peak controller. Spectrophotometric assay was also carried out. A 1 ml sample of actinomycete culture medium was centrifuged and then diluted 2.5 fold with water. Azo dye substrate present was then measured spectrophotometrically (Hewlett-Packard 8452 diode array spectrophotometer operated by PC Vectra computer with HP’s MSTM-DOS/UV-VIS software). The percentage biodegradation of test substance was determined to be 0% i.e; no degradation of test substance was observed by the 15 different Streptomyces spp. Thus, the test substance was considered to be not readily biodegradable in nature.

 

In a supporting weight of evidence study from peer reviewed journal (J. Ruff, et. al; 1999) for the read across chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS no. 118-33-2),biodegradation experiment was conducted for 9 days for evaluating the percentage biodegradability of read across substance 6 -aminonaphthalene-1,3 -disulfonic acid. Test chemical 6 -aminonaphthalene-1,3 -disulfonic acid was purchased from TCI (Tokyo) at the highest purity available. Glassware was cleaned thoroughly and care taken to exclude extraneous sulfur. Pseudomonas putida strain S-313 was used as a test inoculum obtained from activated sludge from sewage treatment plants in Konstanz, Germany (largely communal) and Ludwigshafen, Germany (largely industrial).Initial experiments were done with the phosphate-buffered medium. The sulfur-free acetate-Tris-buffered salts medium gave the same products with negligible background growth, and thus used as a standard medium. Sulfur was provided at 50µM, except for disulfonates, where the initial sulfonate concentration was 30µM.Cultures were grown in screw-capped tubes on a roller at 30°C.Samples were taken at 3-day intervals for 9 days. Bacteria were removed by centrifugation and the protein content measured, and 100µl portions of the supernatant fluid were examined by HPLC. Substrates and products were determined by isocratic reversed-phase high-pressure liquid chromatography (HPLC) or by ion-pair chromatography. The apparatus included a diode array detector. Chromatograms were initially evaluated with wavelength settings of 245 nm for the amino-naphthalenedisulfonates. Protein was assayed by a Lowry-type method.The percentage degradation of test chemical 6 -aminonaphthalene-1,3 -disulfonic acid was determined to be 0% by using Pseudomonas putida strain S-313 as an inoculum. Thus, based on percentage degradation, chemical 6 -aminonaphthalene-1,3 -disulfonic acid can be considered to be not readily biodegradable in nature.

 

Another biodegradation study was conducted for 30 days under aerobic conditions for evaluating the percentage biodegradability of read across substance 6 -aminonaphthalene-1,3 -disulfonic acid (CAS no. 118 -33 -2) (from peer reviewed journal GREIM H., et. al; 1994 and secondary source IUCLID dataset, 2000). The study was performed according to OECD Guideline 301 D "Ready Biodegradability: Closed Bottle Test". Initial test substance conc. used in the study were 3, 10 and 30 mg/l, respectively. The percentage degradation of substance 6 -aminonaphthalene-1,3 -disulfonic acid was determined to be 0% by BOD parameter in 30 days. Thus, based on percentage degradation, 6 -aminonaphthalene-1,3 -disulfonic acid is considered to be not readily biodegradable in nature.

On the basis of above results for target chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (from OECD QSAR toolbox version 3.4 and EPI suite, 2017) and for its read across substance (from peer reviewed journal, authoritative database J-CHECK and secondary source OECD SIDS and IUCLID dataset), it can be concluded that the test substance 5-amino-2-methoxybenzene-1-sulfonic acid can be expected to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0). If released in to the environment, 29.2% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0833%), indicates that 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate is not persistent in sediment.

 

Biodegradation in soil

The half-life period of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 70.7% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate can be considered to be not readily biodegradable in nature.

Bioaccumulation: aquatic / sediment

Various predicted data for the target compound 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672-22-0) and supporting weight of evidence study for its read across substance were reviewed for the bioaccumulation end point which are summarized as below:

 

In aprediction done using the BCFBAF Program(v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 2 -[(4 -amino-3 -methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0). The bioconcentration factor (BCF) of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate is not expected to bioaccumulate in the food chain.

 

In an another prediction done by using Bio-concentration Factor (v12.1.0.50374) module ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017), theBio-concentration Factor (BCF) over the entire pH scale (pH 1 -14) of the test substance 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS no. 26672 -22 -0) was estimated to be 1. This value indicates that the test substance 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was considered to be non-accumulative in aquatic organisms.

 

Bioconcentration Factor (BCF) of test chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated using Chemspider database(ChemSpider, 2017). The bioconcentration factor of test substance 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be 1 at both pH 5.5 and 7.4, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate is not expected to bioaccumulate in the food chain.

 

Another predicted data was estimated usingSciFinder database (American Chemical Society (ACS), 2017) was used for predicting the bioconcentration factor (BCF) of test chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0). The bioconcentration factor (BCF) of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be 1 (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate is not expected to bioaccumulate in the food chain.

 

In a supporting weight of evidence study from authoritative database (J-CHECK, 2017) for the read across chemical 2-amino-5-methylbenzenesulfonic acid (CAS no. 88-44-8),bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of 2-amino-5-methylbenzenesulfonic acid. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study were 2mg/l and 0.2mg/l, respectively. Range finding study involve the TLm (48 hr) 480 mg/l (w/v) on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of substance 2-amino-5-methylbenzenesulfonic acid on Cyprinus carpio was determined to be ≤ 0.4 L/Kg at a conc. of 2mg/l and ≤ 4.0 L/Kg at a conc. of 0.2mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2 -amino-5 -methylbenzenesulfonic acid is not expected to bioaccumulate in the food chain.

 

For the read across chemical 2-(3-((4-Amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)amino)benzenesulphonyl)vinyl disodium sulphate (CAS no. 2580-78-1), bioaccumulation study was conducted on test organism Cyprinus carpio for 28 days for evaluating the bioconcentration factor (BCF value) of 2-(3-((4-Amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)amino)benzenesulphonyl)vinyl disodium sulphate (J-CHECK, 2017).The study was performed according to OECD Guideline 305 (Bioconcentration: Flow-through Fish Test) andother guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study were 1.04mg/land 0.104 mg/l, respectively.Analytical method involve therecovery ratio: Test water :100 % (Only dilution was conducted as the pretreatment in the test water analysis.), Fish : 72.3 %, - Limit of quantitation : Test water : 1st concentration area : 0.094 mg/L, 2nd concentration area : 0.0094 mg/L, Fish : 1.2 microg/g.Range finding study involve the LC50 (48 hr) > 104 mg/l onRice fish (Oryzias latipes). Lipid content of the test organismCyprinus carpiowas determined to be1.24 and 1.41% at the start and end of exposure. The bioconcentration factor (BCF value) of substance 2-(3-((4-Amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)amino)benzenesulphonyl)vinyl disodium sulphate on Cyprinus carpio was determined to be ≤ 1.2 L/Kg at a conc. of 1.04 mg/l and ≤ 13 L/Kg at a conc. of 0.104 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2-(3-((4-Amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)amino)benzenesulphonyl)vinyl disodium sulphate is not expected to bioaccumulate in the food chain.

 

On the basis of above results for target chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (from EPI suite, ACD labs,ChemSpider and SciFinder database, 2017) and for its read across substance (from authoritative database J-CHECK), it can be concluded that the BCF value of test substance2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate ranges from 1.0 – 3.162 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate is not expected to bioaccumulate in the food chain.

Adsorption / desorption

Various predicted data for the target compound 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 6470-17-3) were reviewed for the adsorption end point which are summarized as below:

 

In aprediction done using theKOCWIN Program(v2.00) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the soil adsorption coefficient i.e Koc value of test chemical 2 -[(4 -amino-3 -methoxy phenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0). The soil adsorption coefficient i.e Koc value of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be 19.88 L/kg (log Koc=1.2983)  by means of MCI method (at 25 deg C).

 

The Soil Adsorption Coefficient i.e Koc value of test substance 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS no. 26672 -22 -0) was estimated using Adsorption Coefficient module (v12.1.0.50374) program as Koc 1 (log Koc = 0) at pH range 1-14 respectively(ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017).

 

In an another prediction done by using ChemSpider Database (2017),the Soil Adsorption Coefficient i.e Koc value of test substance 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS no. 26672 -22 -0) was estimated. The adsorption coefficient (Koc) value of substance 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be 1 (Log Koc = 0) at pH 5.5 and 7.4, respectively.

 

Additional soil adsorption coefficient i.e Koc value of test chemical2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (CAS No. 26672 -22 -0)was estimated using the SciFinder database (American Chemical Society (ACS), 2017).The soil adsorption coefficient i.e Koc value of 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate was estimated to be 1 (log Koc = 0) (at 25 deg C).

 

On the basis of above overall results for target chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate (from EPI suite, ACD labs,ChemSpider and SciFinder database,2017), it can be concluded that the Koc value of test substance 2 -[(4 -amino-3 -methoxyphenyl)sulphonyl]ethyl hydrogen sulphate ranges from1–19.88indicating that the test chemical 2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.