Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-870-1 | CAS number: 22252-43-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Both in the absence and presence of S9-mix ZOR-F did not induce a statistically significant or biologically relevant increase in the number of cells with chromosome aberrations in two independent experiments with human lymphocytes. Moreover, ZOR-F tested in the Salmonella typhimurium reverse mutation assay and in the E. Coli reverse mutation assay in concentrations up to 5000 µg/plate did not express any mutagenic potential. All tests were considered valid. Thus, it is concluded that ZOR-F is not expressing genetic toxicity potential in vitro under the experimental conditions described.
Short description of key information:
In vitro genotoxicity of 7-aminodesacetoxycephalosporanic acid was tested in cultured human lymphocytes (chromosomal aberration) and in cultured E. Coli and S. Typhimurium cells (Ames test).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
