1,10-decanediyl diacrylate

Endpoint summary

Description of key information

No experimental toxicokinetic study is available on 1,10-decanediol diacrylate. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, the absorption of 1,10-decanediol diacrylate is expected to be low by oral route (50%), dermal route (50%) and inhalation (100%, worst case).

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

50

Absorption rate - dermal (%):

50

Absorption rate - inhalation (%):

100

Additional information

No experimental toxicokinetic study is available on 1,10 -decanediol diacrylate. However, as per REACH guidance document R7.C (May 2014), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:

- Mean molecular weight: 282 g/mol

- Water solubility: 3.09 mg/L (20°C) (slightly soluble)

- Partition coefficient Log Kow: 5.00

- Vapour pressure: 0.0894 Pa at 25 °C

 

ABSORPTION

The high value of log Kow and the low solubility of 1,10 -decanediol diacrylate are favorable for a low oral absorption.

Indeed, no clinical effects were observed after one single administration (2000 mg/kg) of 1,10 -decanediol diacrylate by gavage (oral route) in rats. An oral absorption is expected to be low for 1,10 -decanediol diacrylate.

 

With a solubility of 3 mg/L, dermal absorption is anticipated to be low to moderate. A Log Kow of 5 suggests that the rate of penetration of the substance may be limited by the rate of transfer between the stratum corneum and the epidermis. However, a molecular mass smaller than 500 g/mol are favourable to a dermal absorption. The acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, the dermal absorption of 1,10 -decanediol diacrylate is anticipated to be low. The low dermal absorption can be confirmed in the dermal acute toxicity study, where no systemic effect or mortality were observed in rats treated with 2000 mg/kg bw. However, 1,10 -decanediol diacrylate showed allergic reaction in the LLNA: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose.

 

Based on the low value of the vapour pressure (<0.1 Pa), 1,10 -decanediol diacrylate is not a volatile substance. Moreover, the absorption by inhalation can be expected to be low for 1,10 -decanediol diacrylate based on the values of water solubility and log kow.

 

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of 1,10 -decanediol diacrylate. No organ toxicity was showed in the studies.

 

ELIMINATION

Due to the low water solubility and the low molecular mass (282 g/mol), the excretion of 1,10 -decanediol diacrylate in the urines is expected to be low.An excretion via bile and faeces is possible.