Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 232-007-1 | CAS number: 7783-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the acute inhalation toxicity test, Deichmann and Gerarde stated that NF3 is a pulmonary irritant; however classical clinical signs of respiratory irritation, i.e. tachypnea and gasping are likely to be due to anoxia resulting from methaemoglobin formation, rather than direct respiratory irritation. Therefore, no specific testing for respiratory irritation is considered necessary.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Whilst both skin and eye irritation data for NF3 are lacking, no significant signs of skin irritation have been reported in the animal experiments. The majority of animal experiments have reported that NF3 causes clinical signs of eye irritation, irrespective of the species. However, the eye irritation occured during exposure only and did not persist following withdrawal of exposure. In the acute inhalation toxicity test, Deichmann and Gerarde stated that NF3 is a pulmonary irritant; however classical clinical signs of respiratory irritation, i.e. tachypnea and gasping are likely to be due to anoxia resulting from methaemoglobin formation, rather than direct respiratory irritation. Therefore, no specific testing for respiratory irritation is considered necessary.
Justification for selection of skin irritation / corrosion endpoint:
As nitrogen trifluoride is a gas, the dermal route of exposure is not relevant
Justification for selection of eye irritation endpoint:
This study does not need to be conducted as the substance is a gas. Evidence from whole body exposure studies document clincial signs of eye irritation during exposure only, which did not persist following withdrawal from exposure.
Justification for classification or non-classification
Skin irritation: no classification required.
Eye irritation: no classification required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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