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EC number: 223-943-1 | CAS number: 4130-08-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Mar 19 Apr 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- according to the Japanese GLP Standard
Test material
- Reference substance name:
- Trimethoxyvinylsilane
- EC Number:
- 220-449-8
- EC Name:
- Trimethoxyvinylsilane
- Cas Number:
- 2768-02-7
- IUPAC Name:
- trimethoxy(vinyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Silane, ethenyltrimethoxy-
- Molecular formula: C5H12O3Si
- Molecular weight: 148.234
- Physical state: clear colorless liquid
- Analytical purity: 99.8%
- Lot/batch No.: 308595
- Stability under test conditions: verified with IR at the initiation and at the end of the study
- Storage condition of test material: in the dark and cool
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
PHYSICO-CHEMICAL PROPERTIES
- Melting point: < 0°C
- Boiling point: 123°C
- Vapour pressure: < 2.7 kPa at 25 °C
- Water solubility (under test conditions): low
- Stability in water: Test item is hydrolyzed (half-life: within 30 min)
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: sampled directly by each vessel and pre-treatment was not performed
- Sample storage conditions before analysis: no storage before analysis
- Methanol was measured, since the test item was quickly hydrolyzed
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: test item was measured and diluted in dilution water with stirring for 120 min
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: Incorporated Administrative Agency, National Institute for Environmental Studies, Tsukuba, Japan
- Age of parental stock (mean and range, SD): within 24 hours
- Feeding during test: yes
- Food type: Chlorella vulgaris
- Amount: 0.15 mgC/animal/day
ACCLIMATION
- Acclimation period: 2006-03-08 ~ 2006-03-29
- Acclimation conditions (same as test or not): similar to test (acclimation condition: water was changed three times a week, test condition: water was changed every day)
- Type and amount of food:Chlorella vulgaris, 0.2 mgC/animal/day
- Health during acclimation (any mortality observed): < 5% during 2 weeks before exposure
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- 240 - 250 (as CaCO3) mg/L, measured at day 0, 7, 14, 15 and 21 in the freshly prepared test solution and at day 1, 8, 15 and 21 in the old test solution before renewal.
- Test temperature:
- 19.7 - 20.2 °C, measured at day 0, 7, 14, 15 and 21 in the freshly prepared test solution and at day 1, 8, 15 and 21 in the old test solution before renewal.
- pH:
- 7.1 - 8.4, measured at day 0, 7, 14, 15 and 21 in the freshly prepared test solution and at day 1, 8, 15 and 21 in the old test solution before renewal.
- Dissolved oxygen:
- 4.4 - 8.8 mg/L (> 3mg/L), measured at day 0, 7, 14, 15 and 21 in the freshly prepared test solution and at day 1, 8, 15 and 21 in the old test solution before renewal.
- Nominal and measured concentrations:
- Nominal concentration: 12, 21, 38, 67 and 120 mg/L
Time-weighted mean: 7.2, 14.6, 28.1, 52.4 and 99.8 mg/L
The measured concentration was calculated based on the concentration of methanol yielded on hydrolysis - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL beaker
- Type (delete if not applicable): closed with a Teflon sheet
- Material, fill volume: glass, 80 mL
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): once a day
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Culture medium different from test medium: same medium
OTHER TEST CONDITIONS
- Adjustment of pH: no adjustment
- Photoperiod: 16 hours in the light, 8 hours in the dark
- Light intensity: < 800 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
mortality and general condition (abnormal behavior) of parental animals, cumulative number of juveniles and time to first brood production were observed every day.
RANGE-FINDING STUDY
- Test concentrations: 120 mg/L (nominal concentration)
- Results used to determine the conditions for the definitive study: An acute toxicity test of daphnia magna was performed and EC50 for 48 hours was > 120 mg/L. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate (analytical grade)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 28.1 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- cumulative number of juveniles per adult
- Remarks on result:
- other: The measured concentration was calculated based on the concentration of methanol yielded on hydrolysis
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 52.4 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- cumulative number of juveniles per adult
- Remarks on result:
- other: The measured concentration was calculated based on the concentration of methanol yielded on hydrolysis
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 119 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: (95% CL 104 - 149 mg/l; extrapolated from effects at conc. 14.6-99.8 mg/l).
- Details on results:
- - Mortality of parent animals: see Table 2
- No. of offspring produced per day per female: see Table 3
- Time to first brood release or time to hatch: Control: 8 - 9 days, 7.2 mg/L: 8 - 9 days, 14.6 mg/L: 8 - 13 days, 28.1 mg/L: 8 - 9 days, 52.4 mg/L: 8 - 9 days, 99.8 mg/L: 9 - 15 days - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Relevant effect levels: EC 50 was 0.75 ± 0.14 mg/L - Reported statistics and error estimates:
- Logit test for EC50, Williams's multicomparison test for NOEC and LOEC
Any other information on results incl. tables
Table 1. Calculated concentration of the test item using methanol concentration in test water
Nominal concentration (mg/L) |
|
Measured concentration (mg/L) |
TWM (*1) (% of nominal) |
|||||
Date |
0 new |
1 old |
14 new |
15 old |
20 new |
21 old |
||
Control |
<0.05 |
<0.05 |
<0.05 |
<0.05 |
<0.05 |
<0.05 |
- |
|
12.0 |
10.1 |
10.5 |
9.75 |
7.21 |
10.3 |
0.32 (*2) |
7.20 (60) (*3) |
|
21.0 |
19.2 |
17.6 |
17.1 |
13.5 |
15.6 |
6.01 |
14.6 (70) |
|
38.0 |
33.5 |
32.0 |
31.1 |
20.2 |
31.6 |
21.5 |
28.1 (74) |
|
67.0 |
57.3 |
51.3 |
60.3 |
37.6 |
67.4 |
44.3 |
52.4 (78) |
|
120 |
104 |
96.4 |
102 |
77.0 |
120 |
101 |
99.8 (83) |
New: Freshly prepared test solution
Old: Old test solutions before renewal
*1: Time-weighted mean calculated concentration during 21 days
*2: This value is estimate because it is not within the range of the calibration curve.
*3: This value is given for reference because of containing the estimate value.
Table 2. Mortality of parental Daphnia
Nominal concentration (mg/L) |
Mean measured concentration (mg/L) |
Cumulative Number of Dead (Percent Mortality) |
|||||
Day 1 |
2 |
4 |
7 |
14 |
21 |
||
Control |
- |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
12.0 |
7.20 |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
21.0 |
14.6 |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
38.0 |
28.1 |
0 (0) |
1 (10) |
1 (10) |
1 (10) |
1 (10) |
1 (10) |
67.0 |
52.4 |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
120 |
99.8 |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
12.0 |
7.20 |
0 (0) |
0 (0) |
0 (0) |
1 (10) |
1 (10) |
1 (10) |
Table 3. Cumulative number of juveniles produced per adult alive for 21 days
Nominal Conc., mg/L
|
Calculated Cnc., mg/L |
Mean Cumulative Numbers of Juveniles ± S.D. |
Inhibition Rate (%) |
Significant difference |
Control |
- |
107.8 ± 13.8 |
|
|
12.0 |
7.20 |
123.7± 8.1 |
-14.7 |
- |
21.0 |
14.6 |
124.5 ± 18.9 |
-15.5 |
- |
38.0 |
28.1 |
108.0 ± 19.4 |
-0.2 |
- |
67.0 |
52.4 |
95.7 ± 17.2 |
11.2 |
** |
120 |
99.8 |
69.8 ± 16.5 |
35.5 |
** |
-: indicates no significant difference
**: indicates a significant difference (α = 0.01) from the control.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 21 day NOEC of 2768-02-7 was measured to be 28.1 mg/l. Due to the rapid rate of hydrolysis the concentration was based on the measured concentration of the hydrolysis product, methanol.
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