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Diss Factsheets
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EC number: 222-217-1 | CAS number: 3388-04-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
In a study designed to investigate the dermal oncogenic potential of 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane (Union Carbide Corporation, 1979), in the group of mice treated with the test substance, four mice developed squamous cell carcinomas of the skin of the treatment area. The negative and positive controls gave appropriate results. Due to the limitations of the study design the results contribute to a weight of evidence for carcinogenicity of 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 25
- Study duration:
- chronic
- Species:
- mouse
Justification for classification or non-classification
Additional information
In a study designed to investigate the dermal oncogenic potential (Union Carbide Corporation, 1979), 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane was assessed by applying 25µl aliquots of undiluted test substance to the shaved skin of 40 male C3H/HeJ mice. A negative control group of a similar size received the same volume of acetone only and a positive control group received 0.1% methylcholanthrene in acetone. All substances were applied to the skin of the back three times weekly until the death of the animals. In the group of mice treated with the test substance, four mice developed squamous cell carcinomas of the skin of the treatment area. Although two further mice were noted with subcutaneous tumours (a fibrosarcoma and a myxofibrosarcoma) outside of the treatment area these were considered not to be attributable to treatment. No skin neoplasms were observed in the group treated with acetone although two mice had subcutaneous sarcomas (fibrosarcoma and lymphosarcoma) outside of the treatment area. Both of these sarcomas were unusual and had never been seen in similarly treated control mice in the laboratory concerned. The positive control group had 39 animals with skin tumours including 33 with confirmed squamous cell carcinomas. No significant signs of irritation were observed in any group. Silicone A-186 was considered by the study authors to be tumorigenic when applied to the skin of C3H mice under the conditions of this study.
Justification for selection of carcinogenicity via dermal route endpoint:
The study was conducted according to a scientific principle and adds to the weight of evidence.
Carcinogenicity: via dermal route (target organ): other: skin
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