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EC number: 212-603-8 | CAS number: 831-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as-
2. and 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- yes
- Remarks:
- and 3. not specified
- Buffers:
- 2.
Composition of buffer:
pH 4: 0.4 mL of 0.1 mol/L NaOH and 10 mL of 0.5 mol/L potassium acid phthalate were filled up to 100 mL with purified water.
pH 7: 29.6 mL of 0.1 mol/L NaOH and 10 mL of 0.5 mol/L monopotassium phosphate were filled up to 100 mL with purified water.
pH 9: 21.3 mL of 0.1 mol/L NaOH, 10 mL of 0.5 mol/L H3BO3 in 0.5 mol/L KCL were filled up to 100 mL with purified water.
3. No data available - Duration:
- 5 d
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.05 mg/L
- Remarks:
- 2. The study was performed at pH 4, 7 and 9, respectively.
- Temp.:
- 50 °C
- Remarks:
- 3. Other details not known
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Temp.:
- 50 °C
- Remarks on result:
- other: 2. The study was performed at pH 4, 7 and 9, respectively. Although the half-life value of test chemical was not, but the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water.
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: Other details not known
- Details on results:
- 2. The residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water.
3. The half-life value of test chemical was determined to be > 1 yr at a temperature of 50⁰C. - Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range.The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C.Test substance was added in the test water of pH 4, pH 7 and pH 9 to be the test concentration of about 0.05 mg/L. These test solutions were shaked for 5 days at 50 degree C. After that, the test chemical concentration of each test water was measured and compared with the initial concentration. Analytical method involve the use of HPLC. L-column ODS (15 cm x 4.6 mm I.D.) was used as a column for the study.Although the half-life value of test chemical was not known, but the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50⁰C and at pH 4, 7 and 9, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
For the test chemical, the half-life of the test chemical was determined.The study was performed at a temperature of 50⁰C. Test chemical was reported to be hydrolytically stable with a corresponding half-life value of> 1 yrat a temperature of 50⁰C, respectively.Thus, based on the half-life value, it is concluded that the test chemical is not hydrolysable in water.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Reference
2.
pH |
Initial concentration |
Concentration after 5 days |
Residue |
Average residue |
pH 4.0 |
10.7 mg/L |
10.8 mg/L |
100 % |
100 % |
10.8 mg/L |
100 % |
|||
pH 7.0 |
10.6 mg/L |
10.8 mg/L |
102 % |
102 % |
10.8 mg/L |
102 % |
|||
pH 9.0 |
10.7 mg/L |
10.5 mg/L |
98.5 % |
98.5 % |
3. No data available
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C.Test substance was added in the test water of pH 4, pH 7 and pH 9 to be the test concentration of about 0.05 mg/L. These test solutions were shaked for 5 days at 50 degree C. After that, the test chemical concentration of each test water was measured and compared with the initial concentration. Analytical method involve the use of HPLC. L-column ODS (15 cm x 4.6 mm I.D.) was used as a column for the study. Although the half-life value of test chemical was not known, but the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50⁰C and at pH 4, 7 and 9, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
For the test chemical, the half-life of the test chemical was determined. The study was performed at a temperature of 50⁰C. Test chemical was reported to be hydrolytically stable with a corresponding half-life value of> 1 yrat a temperature of 50⁰C, respectively. Thus, based on the half-life value, it is concluded that the test chemical is not hydrolysable in water.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and a temperature of 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
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