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Diss Factsheets
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EC number: 208-175-7 | CAS number: 513-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1-dichloroacetone
- EC Number:
- 208-175-7
- EC Name:
- 1,1-dichloroacetone
- Cas Number:
- 513-88-2
- Molecular formula:
- C3H4Cl2O
- IUPAC Name:
- 1,1-dichloropropan-2-one
- Reference substance name:
- 1,1-Dichloro-2-Propanone
- IUPAC Name:
- 1,1-Dichloro-2-Propanone
- Test material form:
- not specified
- Details on test material:
- 98 % purity
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- Sencar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The test animals utilized were female SENCAR mice (Harlan Sprague-Dawley, Inc., Indianapolis, IN).
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- ethanol
- Details on exposure:
- Doses were applied six times ouer a 2-week period in 0.2 ml ethanol per application.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- A constant dosing volume of 0.2 ml/
mouse was used for both topical and oral
administration. There were either 50 or 60
animals in each exposure group. Two weeks
after the last dose of the test chemicals, a
tumor promotion schedule involving application
of 1.0 pg of 12-O-tetradecanoyl-phorbol-
13-acetate (TPA) in 0.2 ml acetone 3 times
weekly was begun with either 30 (of groups of
50) or 40 (of groups of 60) mice and continued
for 20 weeks. The remaining 20 animals in
each group received 0.2 ml acetone only for
the same duration. The incidence of tumors
was charted by location and sized from weekly
observations. Papillomas were included in the
cumulative tumor count only if they were
observed for at least 3 consecutive weeks.
Only those animals surviving through 6 weeks
of promotion were included in the data analysis. - Post exposure period:
- Groups of animals that were found to have
significantly increased incidences of papilloma
were maintained for a total period of 1 year to
allow for the development of carcinoma. At
the time of killing, all gross lesions were noted
and fixed in 10% buffered formalin and
tumors classified histopathologically.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
600, 900, 2400, 3600, and 4800 mg/kg
Basis:
nominal conc.
- Control animals:
- yes, concurrent vehicle
Examinations
- Statistics:
- The percentage of animals with tumors in
each dose group was compared to the percentage
in the corresponding concurrent control
group using the likelihood ratio statistic.
The cumulative tumor count (tumors/animal)
was analyzed for a significant increase over the
concurrent control using the log rank test.
Results were deemed significant at the 0.05 a
level.
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Among the five chlorinated acetone and three chlorinated acroleins and brominated
acrolein tested in the present experiments, only 1,3-DCA, CAC and BAC displayed activity
as tumor initiators in the mouse skin. 1,1-DCA did not induce tumors in the mouse skin.
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