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Inventar tvari u skladu s Prilogom III.

Inventar tvari u skladu s Prilogom III.

ECHA je sastavila inventar tvari koje vjerojatno ispunjavaju kriterije iz Priloga III. Uredbi REACH. Njegova je svrha pomoći podnositeljima registracije da utvrde moraju li ispuniti smanjene zahtjeve za dostavu minimalnih informacija ili dostaviti potpuni skup informacija iz Priloga VII.

Inventar je sastavljen uz pomoć javno dostupnih baza eksperimentalnih podataka i na temelju rezultata dobivenih primjenom modela (Q)SAR. Naznake opasnih toksikoloških ili ekotoksikoloških svojstava kao i informacije o primjenama i ostale dostupne relevantne informacije moraju se usporediti s kriterijima iz Priloga III.

Činjenica da neka tvar nije na tom popisu ne mora značiti da nisu ispunjeni kriteriji iz Priloga III. Slično tomu, ako je neka tvar uvrštena u inventar, podnositelj registracije ipak može iskoristiti mogućnost dostavljanja informacija u smanjenom obujmu ako za to postoji opravdanje.

Napominjemo da popis nije alat za razvrstavanje, nego samo ukazuje na razloge za zabrinutost. Primjerice, činjenica da je tvar naznačena kao „potencijalni mutagen" ne znači da ECHA smatra kako je ta tvar razvrstana kao mutagen. Svi bi se dokazi trebali uzeti u obzir prije nego što se donese odluka o razvrstavanju.

Download the full Annex III Inventory

You can download the full Annex III inventory as XLS format.

Download Annex III Inventory

 

2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane

EC / List no.: 216-823-5 CAS no.: 1675-54-3
Information source
# Harmonised classification for eye irritation: The substance is listed in Annex VI of CLP as: Eye Irrit. 2 # Harmonised classification for skin sensitisation: The substance is listed in Annex VI of CLP as: Skin Sens. 1 # Suspected carcinogen: The Toolbox profiler 'Carcinogenicity (genotox and nongenotox) alerts by ISS' gives an alert for carcinogenicity # Suspected hazardous to the aquatic environment: Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 6.85 mg/L (moderate reliability);The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of 1.87 mg/L # Suspected mutagen: The Toolbox profiler 'DNA alerts for AMES, MN and CA by OASIS v.1.3' gives an alert for mutagenicity; The Toolbox profiler 'in vitro mutagenicity (Ames test) alerts by ISS' gives an alert for mutagenicity; CAESAR Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); ISS Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (moderate reliability); KNN Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (moderate reliability); SARPY Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); mutagen according to ISSSTY # Suspected persistent in the environment: Ready biodegradability model (IRFMN) in VEGA (Q)SAR platform predicts that the chemical is NON Readily Biodegradable (moderate reliability);The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable # Suspected respiratory sensitiser: The Toolbox profiler 'Respiratory sensitisation' gives an alert for respiratory sensitisation # Suspected skin irritant: The Danish QSAR database contains information indicating that the substance is predicted as skin irritant # Suspected skin sensitiser: The Toolbox profiler 'Protein binding alerts for skin sensitization by OASIS v1.3' gives an alert for skin sensitisation; CAESAR skin sensitisation model in VEGA (Q)SAR platform predicts that the chemical is Sensitizer (EXPERIMENTAL value) # Suspected toxic for reproduction: CAESAR developmental toxicity model in VEGA (Q)SAR platform predicts that the chemical is Toxicant (good reliability)

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