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Inventar tvari u skladu s Prilogom III.

Inventar tvari u skladu s Prilogom III.

ECHA je sastavila inventar tvari koje vjerojatno ispunjavaju kriterije iz Priloga III. Uredbi REACH. Njegova je svrha pomoći podnositeljima registracije da utvrde moraju li ispuniti smanjene zahtjeve za dostavu minimalnih informacija ili dostaviti potpuni skup informacija iz Priloga VII.

Inventar je sastavljen uz pomoć javno dostupnih baza eksperimentalnih podataka i na temelju rezultata dobivenih primjenom modela (Q)SAR. Naznake opasnih toksikoloških ili ekotoksikoloških svojstava kao i informacije o primjenama i ostale dostupne relevantne informacije moraju se usporediti s kriterijima iz Priloga III.

Činjenica da neka tvar nije na tom popisu ne mora značiti da nisu ispunjeni kriteriji iz Priloga III. Slično tomu, ako je neka tvar uvrštena u inventar, podnositelj registracije ipak može iskoristiti mogućnost dostavljanja informacija u smanjenom obujmu ako za to postoji opravdanje.

Napominjemo da popis nije alat za razvrstavanje, nego samo ukazuje na razloge za zabrinutost. Primjerice, činjenica da je tvar naznačena kao „potencijalni mutagen" ne znači da ECHA smatra kako je ta tvar razvrstana kao mutagen. Svi bi se dokazi trebali uzeti u obzir prije nego što se donese odluka o razvrstavanju.

Benzo[def]chrysene

EC / List no.: 200-028-5 CAS no.: 50-32-8
Information source
# Harmonised classification for aquatic toxicity: The substance is listed in Annex VI of CLP as: Aquatic Acute 1; The substance is listed in Annex VI of CLP as: Aquatic Chronic 1 # Harmonised classification for carcinogenicity: The substance is listed in Annex VI of CLP as: Carc. 1B # Harmonised classification for mutagenicity: The substance is listed in Annex VI of CLP as: Muta. 1B # Harmonised classification for reprotoxicity: The substance is listed in Annex VI of CLP as: Repr. 1B # Harmonised classification for skin sensitisation: The substance is listed in Annex VI of CLP as: Skin Sens. 1 # Suspected bioaccumulative: Bioaccumulation Canada database in the Toolbox reports at least one value above the B threshold of 2,000 L/Kg (3.3 log units); EpiSuite data included in the Toolbox contain at least one experimental log Kow value equal to or higher than 4.5 # Suspected carcinogen: The Toolbox profiler 'Carcinogenicity (genotox and nongenotox) alerts by ISS' gives an alert for carcinogenicity; CAESAR Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (EXPERIMENTAL value); ISS Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (EXPERIMENTAL value); IARC monographs classified the substance as carcinogenic or probably/possibly carcinogenic; carcinogen according to ISSCAN; reasonably anticipated to be a human carcinogen according to NTP 13th RoC # Suspected hazardous to the aquatic environment: Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 0.2662 mg/L (moderate reliability); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is 'Toxic-2 (between 1 and 10 mg/l) (good reliability)'; Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 1.03 mg/L (moderate reliability) # Suspected mutagen: The Toolbox profiler 'DNA alerts for AMES, MN and CA by OASIS v.1.3' gives an alert for mutagenicity; The Toolbox profiler 'in vitro mutagenicity (Ames test) alerts by ISS' gives an alert for mutagenicity; CAESAR Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); ISS Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); KNN Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (good reliability); SARPY Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); The outcome in CTA assay is positive according to ISSCTA; In vivo micronucleus test outcome positive according to ISSMIC; mutagen according to ISSSTY # Suspected persistent in the environment: The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable # Suspected skin sensitiser: CAESAR skin sensitisation model in VEGA (Q)SAR platform predicts that the chemical is Sensitizer (EXPERIMENTAL value) # Suspected toxic for reproduction: The Toolbox profiler 'DART scheme v.1.0' gives an alert for toxicity to reproduction;Developmental/Reproductive Toxicity library (PG) in VEGA (Q)SAR platform predicts that the chemical is Toxicant (EXPERIMENTAL value); DART database in the Toolbox reports that this substance as Known developmental potential

Download the full Annex III Inventory

You can download the full Annex III inventory as XLS format.

Download Annex III Inventory

 

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