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EC number: 406-040-9 | CAS number: 125643-61-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects occur at the range of solubility.
NOEC(overall effects) >=1 mg/L ( which is far above the water solubility)
Key value for chemical safety assessment
Additional information
Assessment of the parent compound Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-,C7-9-branched alkyl esters (CAS: 125643 -61 -0)
The chronic effects of Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-,C7-9- branched alkyl esters towards Daphnia magna were tested in two GLP-guideline studies according to OECD guideline 211.
In the first study (RCC 2000) a filtrate of supersaturated emulsion with a loading rate of 100mg/L test item was prepared. The undiluted filtrate and the dilutions 1:3.2, 1:10, 1:32 and 1:100 were tested. No auxiliary solvent or emulsifier was used.
At the start of the test medium renewal periods, the test item concentration in the analyzed test medium (the undiluted filtrate of the supersaturated emulsion) was below the limit of quantification of 0.03 mg/l.
Taking into account the survival rates and the reproduction rates of the test animals, the dilution 1:3.2 was the highest treatment of Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-,C7-9-branched alkyl ester tested without toxic effects after the exposure period of 21 days (21 -day NOEC). The undiluted filtrate with a loading rate of 100mg/L was the lowest treatment tested with toxic effects (21 -day LOEC) due to the significant mortality rate and due to the statistically significantly reduced mean reproduction rate of Daphnia magna.
A NOEC equal to a dilution of 1 : 3.2 of the undiluted filtrate (loading rate 100mg/L) was derived from this study.
As the substance is a liquid uvcb substance consisting of homologous structures with a very low water solubility of 0.0005 mg/L no details could be given on the concentration of the substance causing no effects besidesdilution 1:3.2 of filtrate with a loading rate of 100mg/L.
For this reason a second test with a similar study design and lower loading rate of 1mg/L was performed (BASF SE 2012).
A saturated test solution with a loading rate of 1 mg/L was prepared. No vehicle was used and no analytical monitoring was conducted.
No significant mortality (21 d EC0≥1 mg/L) or any adverse effects on reproduction or additional endpoints (i.e. growth, immobile young, time to first brood, or aborted eggs) were observed.
The 21-day effect concentrations in Daphnia magna were obtained based on loading rate (nominal concentration):
LOEC / LOELR > 1mg/L
NOEC / NOELR >= 1mg/L
From these tests it can be concluded that the NOEC Daphnia 21 days is above the solubility. No toxic effects occur in the range of solubility.
Supporting assessment of the impurity Metilox (CAS 6386-38-5)
In a long-term toxicity to aquatic invertebrates test with Daphnia under semi-static conditions, the NOEC based on reproduction was 0.123 mg/L based on measured concentration and 0.16 mg/L based on nominal concentrations. The test concentrations were achieved by dilution of a stock solution mixed with Methanol. Measured concentrations taken at > 1mg/L nominal differed > 20% from nominal concentrations. It can be assumed that the stock solutions and test concentrations > 1mg/L were prepared above the solubility limit.
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