Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- December 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Results derived from valid (Q)SAR models, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification. Additional information from read-across and Skin Irritation Corrosion Rules Estimation Tool.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
- Principles of method if other than guideline:
- OECD QSAR toolbox, EPI (Estimation Programs Interface) Suite™, Read Across and SICRET (Skin Irritation Corrosion Rules Estimation Tool) were applied.
- GLP compliance:
- no
Test material
- Test material form:
- liquid: viscous
- Details on test material:
- batch number: 616F-2072 (NBK-003072-796)
Constituent 1
Results and discussion
Any other information on results incl. tables
- EPI suite: the structures of the selected DD80 peaks are not included in QSAR domain: final SAR results are “undefined”
- Read Across cannot be applied, since no structures similar to the selected DD80 peaks – and with known toxicological information - were found in public sources. Looking at substructures of the peaks, no robust conclusion on skin irritating potential can be drawn.
- SICRET approach cannot be applied on DD80, because it does not cover substances containing a phosphor atom, as the peak 1 (and other peaks in the DD80). For peaks 2, 4+5 and 6+7, it is possible to exclude the skin corrosion, only based on their molecular weight, and not using the other parameters, which make the exclusion rather weak. Additionally, skin irritation cannot be excluded for peaks 2, 4 +5 or 6 +7.
Applicant's summary and conclusion
- Interpretation of results:
- other: Inconclusive
- Conclusions:
- No conclusions could be drawn on skin irritation or corrosion from the predictive tools.
- Executive summary:
OECD QSAR toolbox, EPI (Estimation Programs Interface) Suite™, Read Across and SICRET (Skin Irritation Corrosion Rules Estimation Tool) were applied.
No conclusions could be drawn on skin irritation or corrosion from the predictive tools.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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