Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-688-3 | CAS number: 27841-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
The chemical safety assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to investigate further the toxicity to sediment organisms.
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity to sediment organisms are available for Neopentyl glycol dicaprate (CAS No. 27841-06-1). Only negligible releases into surface waters from sewage treatment plants are expected to take place due to the high adsorption potential of this substance, resulting in an effective removal in sewage treatment plants. Therefore, chronic exposure of sediment organisms is unlikely. Furthermore, the substance is not toxic to aquatic organisms up to the limit of water solubility. Based on the available information, toxicity to sediment organisms is not expected to be of concern.
Intrinsic properties and fate
Neopentyl glycol dicaprate (CAS No. 27841-06-1) is readily biodegradable (> 90% biodegradation after 28 days; OECD 301B). According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological sewage treatment plants (STP) where the substance will be extensively removed in the primary settling tank and fat trap. As a result of the high adsorption potential of the substance (KOCWIN v2.00; MCI method: log Koc=5.2567; log Pow based estimate: log Koc=6.115) a removal from the water column to a significant degree by adsorption to sewage sludge can be expected (Guidance on information requirements and chemical safety assessment, Chapter R.7b, (ECHA, 2017)). Thus, only limited amounts will get in contact with activated sludge organisms in STPs and the concentration of the substance in effluents of conventional STPs is presumably marginal. The rest will be extensively biodegraded (due to ready biodegradability). Thus, discharged concentrations of these substances into the aqueous/sediment compartment are likely to be negligible.
Considering this it can be assumed that the availability of Neopentyl glycol dicaprate (CAS No. 27841-06-1) in the sediment environment is very low, which reduces the probability of chronic exposure of sediment organisms in general.
Aquatic ecotoxicity data
Available acute data from structurally related read-across substances with fish, aquatic invertebrates and algae as well as chronic aquatic toxicity tests from aquatic invertebrates and algae showed that no adverse effects occurred up to the limit of water solubility (< 2.4 µg/L). The results obtained indicate that Neopentyl glycol dicaprate (CAS No. 27841-06-1) is likely to show no toxicity to sediment organisms either.
Metabolism:
After absoprtion Neopentyl glycol dicaprate (CAS No. 27841-06-1) is expected to hydrolyse in vivo, yielding the alcohol 2,2-dimethyl-1,3-propanediol (neopentyl glycol) and decanoic acid. The metabolism of the hydrolysis products, i.e. neopentyl glycol and decanoic acid, is well established and not of concern in terms of bioaccumulation. Both hydrolysis products are presumed to be satisfactory metabolized in aquatic organisms. Therefore, no potential for bioaccumulation is to be expected.
Conclusion
Due to its readily biodegradable nature and its high potential for adsorption to sewage sludge, extensive degradation of Neopentyl glycol dicaprate (CAS No. 27841-06-1) will take place in conventional STPs and only low concentrations are expected to be released (if at all) into the environment. Once present in the aquatic compartment the substance will mainly partition to the sediment particles due to the low water solubility and high adsorption potential. Thus, the substance will be bioavailable to sediment organisms mainly via feed and contact with suspended organic particles. After uptake by sediment species the substance is expected to hydrolyse in vivo, yielding the alcohol 2,2-dimethyl-1,3-propanediol (neopentyl glycol) and decanoic acid. Furthermore, all available aquatic toxicity data show that no acute or chronic effects occur up to the limit of water solubility. Therefore, Neopentyl glycol dicaprate (CAS No. 27841-06-1) is unlikely to pose a risk for sediment organisms and testing is thus omitted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.