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EC number: 277-091-0 | CAS number: 72928-81-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No significant skin sensitising potential in guinea pig maximisation test.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No information was available on the substance itself, thus the assessment relied on a read across approach. Solvent Red 122 and Similar Substance 02 are chromium complexes with 2 ligands. In both cases, the 2 ligands have the same chemical structure, i.e. a phenyl ring connected via diazo bond to a phenyl pyrazole. These ligands show minor differences in the position of substituents, i.e. hydroxy and nitro groups, as well as in the presence of a sulfonate group in Similar Substance 02.
All information about the read across process is inserted in section 13.
Guinea pig maximization study was conducted to evaluate the skin sensitising potential of Similar Substance 02 according to OECD guideline 406 and EU method B.6. Based on the results of a preliminary study, 5 and 50 % were selected as intradermal and topical induction doses respectively. The highest non-irritating test substance concentration used for challenge application was 50 %.
The first challenge with test substance at 50 % gave 60 % positive skin reactions in the control group and 55 % in the test group. Thus, a second challenge was performed with an additional control group. Overall, test substance at 50 % in vaselinum album was determined twice as the highest non-irritating concentration.
However, by comparison, the second challenge did not confirm the first challenge. Indeed, no positive reactions were noted with test article at 50 % in the control group, while 15 % positive reactions were noted in the test group. On these bases, the interpretation is very ambiguous. Further, an additional test substance concentration of 25 % was applied in the second challenge procedure, causing no skin reactions in the control and test group.
Under the conditions of the study, the test substance was not considered to induce delayed contact hypersensitivity in treated animals when tested at the concentration of 25 %.
No toxic symptoms were noted in control and test animals.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), skin sensitizer is a substance that will lead to an allergic response following skin contact. In case of a guinea pig maximisation test, a response of at least 30 % of the animals is considered as positive.
Under the experimental conditions employed, 0 % of the animals of the test and control groups showed skin reactions 24 and 48 hours upon challenge with test substance at 25 % concentration, thus no classification applied.
Based on the read across approach, Solvent Red 122 was considered as non skin sensitising.
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