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EC number: 220-688-8 | CAS number: 2867-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Non-GLP, no details on test substance incl. purity, 48-hour reading missing, short observation period).
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Reference Type:
- publication
- Title:
- Atochem (1980), Skin and Ocular Irritation test, Consultox Lab: CL80 65:2030
- Author:
- Atochem
- Year:
- 2 003
- Bibliographic source:
- cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003
Materials and methods
- Principles of method if other than guideline:
- According to the method described in the Federal Hazardous Substances Labelling Act Regulations, Section 191.11, published in the Federal Register - 29 F.R. 13009, 1964.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-dimethylaminoethyl methacrylate
- EC Number:
- 220-688-8
- EC Name:
- 2-dimethylaminoethyl methacrylate
- Cas Number:
- 2867-47-2
- Molecular formula:
- C8H15NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl methacrylate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No details.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact (shaved) and abraded
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 ml
- Concentration: undiluted - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 4
- Details on study design:
- A 0.5 mL sample of the test material was applied to areas of intact and abraded areas of skin. These areas were then occluded with square surgical gauge patches, each measuring 1 inch x 1 inch. After 24 hrs exposure, the patches were removed and the resulting reactions evaluated. The valuation was done again at 72 hrs.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not examined
- Remarks on result:
- other: Observation period too short for a clear conclusion on reversibility.
- Remarks:
- Only time point 24 and 72 hours were observed.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not examined
- Remarks on result:
- other: Observation period too short for a clear conclusion on reversibility.
- Remarks:
- Only time point 24 and 72 hours were observed.
- Irritant / corrosive response data:
- Severe erythema, oedema and necrosis were exhibited 24 hrs following application. Reactions persisted to 72 hrs. For all animals and for both of
intact skin and abraded skin, maximum score of 4 was marked in the erythema and oedema rating, therefore a Primary Irritation Score of 8.0 was obtained.
Any other information on results incl. tables
Individual skin responses:
Rabbit No. |
Time (hours) |
Intact Skin |
Abraded Skin |
||
Erythema |
Oedema |
Erythema |
Oedema |
||
1 |
24 |
4 |
4 |
4 |
4 |
72 |
4 |
4 |
4 |
4 |
|
2 |
24 |
4 |
4 |
4 |
4 |
72 |
4 |
4 |
4 |
4 |
|
3 |
24 |
4 |
4 |
4 |
4 |
72 |
4 |
4 |
4 |
4 |
|
4 |
24 |
4 |
4 |
4 |
4 |
72 |
4 |
4 |
4 |
4 |
|
5 |
24 |
4 |
4 |
4 |
4 |
72 |
4 |
4 |
4 |
4 |
|
6 |
24 |
4 |
4 |
4 |
4 |
72 |
4 |
4 |
4 |
4 |
|
Mean |
24 |
4 |
4 |
4 |
4 |
72 |
4 |
4 |
4 |
4 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- The test material is considered to be corrosive to the skin.
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