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EC number: 243-900-0 | CAS number: 20592-85-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to Annex 3 of the CSR and IUCLID Section 13 for justification of read-across within the ATMP category.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Conc. / dose:
- 0.14 mg/L
- Type:
- BCF
- Value:
- 22 L/kg
- Basis:
- non-edible fraction
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
- Principles of method if other than guideline:
- Flow-through study with radiolabelled test substance
- GLP compliance:
- no
- Vehicle:
- no
- Details on preparation of test solutions, spiked fish food or sediment:
- STOCK AND TEST SOLUTION AND THEIR PREPARATION: Super stock solutions were prepared by diluting known amounts of labelled and unlabelled test substance with distilled water. Diluter stock solutions were prepared by further dilution with distilled water. Test solutions were prepared using an intermittent-flow proprtional diluter. The specific activities of the super stock solutions were determined to be: 0.14 mg/l stock: 335 ± 24 disintegrations per minute/µg 1.4 mg/l stock solution: 33.2 ± 2.5 dpm/µg
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISMS: Size: 19 ± 2 cm Weight: 39 ± 3 g Pretreatment: acclimated for 30 days before testing. Cumulative mortality less than 2% during holding period Feeding: Dry pelleted ration twice daily ad libitum
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 49 d
- Total depuration duration:
- 14 d
- Hardness:
- 35 mg/l as CaCO3
- Test temperature:
- 18 ± 1.0 °C
- pH:
- 7.1
- Dissolved oxygen:
- > 6.0 mg/l (60% saturation)
- Nominal and measured concentrations:
- Nominal: 0.14 mg/l and 1.4 mg/l
Mean measured: 0.14 mg/l and 1.2 mg/l - Key result
- Conc. / dose:
- 0.14 mg/L
- Type:
- BCF
- Value:
- 22 L/kg
- Basis:
- non-edible fraction
- Elimination:
- yes
- Conclusions:
- BCF values of BCF <4 - 22 were determined in a reliable study conducted according to generally accepted scientific principles.
Referenceopen allclose all
BIOACCUMULATION AT 0.14 mg/l
NOMINAL TEST CONCENTRATION: A mean fish concentration of 3.1 mg/kg, equivalent to BCF = 22, was determined for non-edible tissues, although no meaningful trends in bioaccumulation were observed at 7 sampling points over the exposure period. Analysis of the gut, faeces and visceral
tissues at Day 42 showed that 72% of residues were present in faecal matter, 16% in the gut and 12% in the remaining visceral tissues, indicating that the substance was ingested and eliminated with very little accumulation. Expressed on a whole-body basis,
the mean fish concentration was < 0.6 mg/kg, equivalent to BCF < 4.
BIOACCUMULATION AT 1.4mg/l
NOMINAL TEST CONCENTRATION: A similar pattern to the lower test concentration was The mean fish concentration determined for non-edible tissues was 12.2 mg/kg, equivalent to BCF = 10. Analysis on Day 42 showed 45% in faecal matter, < 5% in the gut and 50% in the remaining
visceral tissues. Accumulation in edible tissues was not observed. ELIMINATION: Elimination of the test substance from non-edible tissues was rapid and extensive. After the 14 day depuration, 96% of accumulated
substance was eliminated at the 0.14 mg/l nominal test concentration; 93% was eliminated at the 1.4 mg/l nominal test concentration.
Description of key information
Based on the measured BCF 22 L/kg wwt, ATMP-xNa is not expected to bioaccumulate.
Key value for chemical safety assessment
- BCF (aquatic species):
- 22 L/kg ww
Additional information
- ATMP is present as ATMP-H or one of its ionised forms. The degree of ionisation depends upon the pH of the media and not whether ATMP (3-5K) salt, ATMP (3-5Na) salt, ATMP-H (acid form), or another salt was used for dosing.
- Disassociated potassium, sodium or ammonium cations. The amount of potassium or sodium present depends on which salt was dosed.
- It should also be noted that divalent and trivalent cations would preferentially replace the sodium or potassium ions. These would include calcium (Ca2+), magnesium (Mg2+) and iron (Fe3+). These cations are more strongly bound by ATMP than potassium, sodium and ammonium. This could result in ATMP-dication (e.g. ATMP-Ca, ATMP-Mg) and ATMP-trication (e.g. ATMP-Fe) complexes being present in solution.
There is a report of bioaccumulation of ATMP-H in carp, with a bioconcentration factor in the exposure phase of <4 - 22 L/kg wwt (Monsanto, 1976). A secondary source reports results of a separate test as BCF = 17.7 measured for ATMP-H in Brachydanio rerio (zebra fish) (Steber and Wierich, 1987).
The acid, sodium, potassium and ammonium salts in the ATMP category are freely soluble in water. The ATMP anion can be considered fully dissociated from its sodium, potassium or ammonium cations when in dilute solution. Under any given conditions, the degree of ionisation of the ATMP species is determined by the pH of the solution. At a specific pH, the degree of ionisation is the same regardless of whether the starting material was ATMP-H, ATMP.4Na, ATMP.7K or another salt of ATMP.
Therefore, when a salt of ATMP is introduced into test media or the environment, the following is present (separately):
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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