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EC number: 215-686-9 | CAS number: 1344-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 November 1986 - 30 December 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was not performed under GLP. OECD 402 was followed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium tetrasulphide
- EC Number:
- 234-805-5
- EC Name:
- Disodium tetrasulphide
- Cas Number:
- 12034-39-8
- Molecular formula:
- Na2S4
- Details on test material:
- Chemical name: Disodium tetrasulphide (natriumtetrasulfid)
Appearance: Ocherous solid
Batch number: Na2S4-1
No CoA inlcuded in the study, no information on purity and composition of the test substance. For additional information see attached document.
In the results section of the report the test substance is described as a dark red solid. In the test substance information the test substance is described as an ocherous solid.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Weisse Russen (albino)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: Males 15 - 28 weeks, females 15-21 weeks
- Weight at study initiation: Males 1.88 - 2.27 kg, females 1.86 - 2.32 kg
- Fasting period before study: On the day of application food was withheld.
- Housing: steel cages, bar floor, model asta. One animal per cage.
- Diet (e.g. ad libitum): Ad libitum, standard food for rabbits, ssniff(K).
- Water (e.g. ad libitum): Ad libitum.
- Acclimation period: minimal 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 15
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 26 November 1986 - 30 December 1986
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: between the shoulder and hipbone
- % coverage: no data
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): after 24 hours the skinned was whiped clean with water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 g test substance per 0.5 ml water
- Concentration (if solution): 2g/ml
- Constant volume or concentration used: yes
- For solids, paste formed: yes - Duration of exposure:
- 24 hours
- Doses:
- 200, 633, 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed 6-8 hours after the apllication of the test substance. After the first days animals were observed daily. Time of death and number of animals are recorded. Check for mortality was performed twice daily duringw eek days and once a day in the weekend. Clinical signs and severity, time of onset and duration are recorded.
Bodyweights are determined immediatly after dosing after 7 days and after 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: None - Statistics:
- Graphic average separate for males and females.
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 590 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 650 mg/kg bw
- Mortality:
- In the male 2000 mg/kg dose group 2 out of 3 animals died. 1: 2 hours after application and 1: 24 hours after application. In the female 2000 mg/kg bw group 3 out of 3 animals died. 1: 0.5 hours after applicationa and 2: 1 hour after application. In the female 633 mg/kg bw group 2 out of 3 animals died. 1: 1 hours after application and 1: 2 hours after application.
- Clinical signs:
- other: General bad appearance, cyanosis, labored breathing. Before death general reflex loss was observed. In the female animals vocalisation, red foam from the mouth and nose was observed. First symptoms were observed 40 minutes after application of the test s
- Gross pathology:
- In the animals that died during the study the lungs were colored dark red and in the high dose group 2 animals showed balckening of the lungs.
The animals that were sacrificed at the end of the study showed no abnormalities. Form one of the animals the lungs were investigated more closely and acute hyperaemia with moderate intaaveolair oedema was observed. - Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The LD50 in female animals was estimated at 590 mg/kg bw. The LD50 for males was estimated at 1650 mg/kg bw.
- Executive summary:
For the determination of the acute dermal toxicity disodium tetrasulphide was applied to the skin on the back of 3 groups of male and female rabbits (3/dose/sex). Doses were 200, 633, 2000 mg/kg bw. The animals were exposed for 24 hours and under occlusion. The study was performed according to OECD 402. In the male 2000 mg/kg dose group 2 out of 3 animals died. 1: 2 hours after application and 1: 24 hours after application. In the female 2000 mg/kg bw group 3 out of 3 animals died. 1: 0.5 hours after applicationa and 2: 1 hour after application. In the female 633 mg/kg bw group 2 out of 3 animals died. 1: 1 hours after application and 1: 2 hours after application. General bad appearance, cyanosis, labored breathing. Before death general reflex loss was observed. In the female animals vocalisation, red foam from the mouth and nose was observed. First symptoms were observed 40 minutes after application of the test substance and remained for 3 days. A dosis of 200 mg/kg did not lead to any clinical signs. The skin of all animals showed scabs after removal of the test substance at 24 hours. In the animals that died during the study the lungs were colored dark red and in the high dose group 2 animals showed blackening of the lungs. The animals that were sacrificed at the end of the study showed no abnormalities. Form one of the animals the lungs were investigated more closely and acute hyperaemia with moderate intraveolair oedema was observed. The LD50 in female animals was estimated at 590 mg/kg bw. The LD50 for males was estimated at 1650 mg/kg bw.
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