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Diss Factsheets
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EC number: 202-464-1 | CAS number: 95-92-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: The acute oral LD50 was determined to be 400 - 1600 mg/kg bw in rats (handbook information)
Dermal: The acute dermal LD50 was determined to be > 2000 mg/kg bw in rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 400 mg/kg bw
- Quality of whole database:
- Handbook information, for further information please refer to discussion.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- GLP and guideline study, whole database factor: 1.
Additional information
Acute toxicity oral: In accordance with column 2 of REACH Annex VIII, the acute toxicity oral does not need to be conducted as the substance is classified as corrosive to the skin. According to the criteria in CLP Annex 1, the dose range for acute oral toxicity category 4 is defined as >300 but <=2000 mg/kg bw. The acute oral LD50 of DEO in rats is described with a dose range of 400 - 1600 mg/kg bw (Patty, 1963). Massive renal oxalate deposits were observed following treatment with 400 mg/kg bw or higher in rats. In a 14-day oral gavage dose range finding study (summarized in Research Institute for Organic Syntheses Inc., 2011b) all rats dosed at 600 mg/kg bw/d (5m/5f) died between application day 5 and 14, whereas no death occurred at 300 mg/kg bw/d. This demonstrates that the acute oral LD50 is >300 mg/kg bw/d. Therefore, the classification as Category 4, H302: Harmful if swallowed for the acute oral toxicity is justified.
Acute toxicity dermal: The test substance applied at a dose of 2000 mg/kg bw did not result in death of the treated animals. No clinical signs of intoxication were observed. Macroscopic changes in kidneys (increase in size, changes of colour, granular or rough surface) were diagnosed during gross pathological examinations in four of five male and all female animals. On the basis of these findings, a histopathological examination of the kidneys was performed in one male and female animal. Urolithiasis and interstitial inflamation were observed. According to the results of this study, the LD50 (dermal) of the test substance, Diethyl oxalate, for rats of both sexes is higher than 2000 mg/kg bw. Concurrently the test substance caused severe damage of kidneys at a dose level of 2000 mg/kg bw, detected by gross pathological and histopathological examinations.
Acute toxicity inhalation: In accordance with column 2 of REACH Annex VIII, the acute toxicity inhalation study does not need to be conducted as Diethyl oxalate is classified as corrosive to skin.
Justification for classification or non-classification
Diethyl oxalate is harmful after oral administration (acute oral Cat. 4, H302: Harmful if swallowed) according to the criteria of Regulation (EC) No 1272/2008.
Classification for acute dermal or inhalation toxicity is not warranted according to the criteria of Regulation (EC) No 1272/2008.
The ECHA Guidance on the Application of the CLP Criteria (ECHA 2008) acknowledges that acute toxicity refers to lethality and STOT-SE to non lethal effects. Care should be taken not to assign both classes for the same toxic effect, essentially giving a “double classification”, even where the criteria for both classes are fulfilled. In such case the most appropriate class should be assigned.
DEO caused lethality, and in the absence of lethality adverse effects in the kidney after acute single exposure. As kidney effects were also observed after repeated exposure, classification as STOT RE cat. 2 (kidney) in addition to acute oral cat. 4 sufficiently classifies the health effects of DEO. STOT-SE does not need to be further assigned in accordance to Regulation (EC) No. 1272/2008, in order to prevent “double classification”.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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