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EC number: 272-805-7 | CAS number: 68912-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to a method similar to OECD 404, prior to GLP. Results are acceptable as basic data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- pre GLP-test
Test material
- Reference substance name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl propionate
- EC Number:
- 272-805-7
- EC Name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl propionate
- Cas Number:
- 68912-13-0
- Molecular formula:
- C13H18O2
- IUPAC Name:
- Reaction mass of 3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yl propionate and 3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yl propionate
- Test material form:
- liquid
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 9 - 12 weeks old
- Animals in the telgen phase of hair growth were selected
- Dorsal surface was clipped 3-4 days before dosing
ENVIRONMENTAL CONDITIONS
no data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: control substances were tested simultaneously
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 4 hours exposure
- Observation period:
- 24, 48 and 72 hours after treatment
- Number of animals:
- 8 animals
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm2 cotton gauze was used
- Type of wrap if used: A piece of flexible polythene (3 x 3 cm) was attached to a piece of zinc oxide plaster (9 x 2.5 cm). A 2.5 cm2 cotton gauze (8 ply folded in two) was laid on the polythene such that the edges of the pad are attached to the zinc oxide plaster.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After removal of the patches, the treated sites were wiped.
- Time after start of exposure: 4 hours
SCORING SYSTEM: Erythema, oedema, cracking and scaling were scored using an 8-point scale ranging from 'a' (very slight) to 'h' (severe)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Animal 6
- Irritation parameter:
- erythema score
- Basis:
- animal: 1, 2, 5, and 7
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Animal 1, 2, 5, and 7
- Irritation parameter:
- erythema score
- Basis:
- animal: 3, 4, and 8
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: Animal 3, 4, and 8
- Irritation parameter:
- edema score
- Basis:
- animal: 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Animal 6
- Irritation parameter:
- edema score
- Basis:
- animal: 2 and 5
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Animal 2 and 5
- Irritation parameter:
- edema score
- Basis:
- animal: 1, 3, 4, and 7
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: Animal 1, 3, 4, and 7
- Irritation parameter:
- edema score
- Basis:
- animal: 8
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: Animal 8
- Irritant / corrosive response data:
- Cyclaprop produced a mild reaction 72 hours after treatment. This reaction was greater than diethyl phthalate (which produced virtually no response) and less than that produced by cyclamen aldehyde and gerianiol (which produced severe reactions).
Any other information on results incl. tables
Skin reactions of florocyclene in each animal according to original scoring system:
Animal number |
24h |
48h |
72h |
|||
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
|
1966 |
a |
a |
- |
a |
- |
a |
1969 |
a |
a |
a |
b |
- |
- |
1924 |
a |
a |
a |
a |
a |
a |
1944 |
a |
b |
b |
a |
a |
b |
1945 |
a |
a |
a |
a |
- |
- |
1974 |
- |
- |
- |
- |
- |
- |
1970 |
a |
a |
- |
a |
- |
a |
1920 |
b |
c |
b |
b |
a |
a |
Individual scores after conversion to OECD404 scoring system are summarized in the table below:
Animal number |
24h |
48h |
72h |
|||
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
|
1966 |
1 |
1 |
0 |
1 |
0 |
1 |
1969 |
1 |
1 |
1 |
1 |
0 |
0 |
1924 |
1 |
1 |
1 |
1 |
1 |
1 |
1944 |
1 |
1 |
1 |
1 |
1 |
1 |
1945 |
1 |
1 |
1 |
1 |
0 |
0 |
1974 |
0 |
0 |
0 |
0 |
0 |
0 |
1970 |
1 |
1 |
0 |
1 |
0 |
1 |
1920 |
1 |
2 |
1 |
1 |
1 |
1 |
The difference in irritation score (original scoring system) between the test material (Cyclaprop) and the standards for comparison are all significant.
Diethyl phthalate | Cyclaprop (test material) | Geraniol | Cyclamen aldehyde | |
Overall irritation score | 7 | 85 | 215 | 244 |
Mean score per site | 0.88 | 10.63 | 26.88 | 30.5 |
Mean score per site per day | 0.22 | 2.66 | 6.72 | 7.63 |
Mean irritation ranking | 1.0 | 2.13 | 3.13 | 3.75 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not a skin irritant
- Remarks:
- according to EU CLP (EC 1272/2008 and its amendments)
- Conclusions:
- In the in vivo rabbit skin irritation test according to OECD TG 404, the substance is not a skin irritant.
- Executive summary:
8 New Zealand White rabbits were used to determine the skin irritation potential of test substance Cyclaprop. The whole dorsal surface of the animals was clipped and 0.5 ml of each substance was applied under semi-occlusion to the skin of the animals. After 4 hours, the patch was removed and exposure sites wiped clean. The skin sites were assessed immediately after treatment and 24, 48 and 72 hours after treatment. Cyclaprop produced a mild reaction 24 hours after treatment, which decreased at 48 and 72 hr. The mean erythema scores over the 24, 48 and 72 hour time period, were 0 (1 animal), 0.67 (4 animals) and 1 (3 animals). The mean edema scores over the 24, 48 and 72 hour time period, were 0 (1 animal), 0.67 (2 animals), 1 (4 animals), and 1.33 (1 animal). As all animals had scorings below 2.3, the test substance is not considered to be a skin irritant.
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