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Diss Factsheets
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EC number: 272-805-7 | CAS number: 68912-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
In the decision letter from ECHA of 21 October 2021 (CCH-D-2114569822-39-01/F) Long-term toxicity testing on terrestrial invertebrates (OECD TG 222 or 220 or 232) or a Long-term toxicity test to terrestrial plants (OECD TG 208 with at least six species or ISO 22030) with Cyclaprop was requested. Based on the substance properties, it was decided by the lead registrant to conduct an OECD TG 222. The deadline for submission is January 26th 2023, but unfortunately, the test report will not be available before that date. Quotations from several labs were requested, but due to non-availability of some labs, it took some time to find the right lab to perform the study on the shortest notice. The OECD 222 study will be initiated on 23 February 2023 and the final results are expected to be available by the end of June 2023. The dossier will be updated as soon as possible after receiving the final reports. A letter from the test lab showing the timelines is attached to this endpoint summary.
Cyclaprop's earthworm EC10 is 45 mg/kg soil dw based on read across from Verdox, which was tested in an OECD TG 222.
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 45 mg/kg soil dw
Additional information
The read across to Cyclaprop is presented in the Terrestrial toxicity Overall Endpoint summary. The executive summary of the Verdox long-earthworm study is presented below.
The executive summary of the Verdox long-term earthworm study
The long-term toxicity of Verdox to earthworm Eisenia foetida was tested in an OECD TG 222 study. The test material was dissolved in equal amounts of acetone, mixed with quartz sand and allowed to slowly evaporate and mixed with the standard soil containing 10% Sphagnum peat, 20% kaolinite clay, approximately 70% fine quartz-sand (grain size 0.05 -0.2 mm) and 0.4% calcium carbonate to adjust to pH 6.0±0.5. Adult worms were exposed to nominal concentrations in soil of 5, 15.8, 50, 158.1 and 500 mg/kg dw soil. Weights of the adult worms ranged between 322 and 596 mg. The worms were fed weekly with finely ground cattle manure. Adult worms were removed after 4 weeks of exposure, counted and weighed. The remaining offspring remained in the test containers for another four weeks. Nominal concentrations are used to present the effects. No worms survived at 500 mg/kg soil dw. The NOEC for mortality and growth was 158.1 mg/kg dw. The EC10 for reproduction was 45.1 mg/kg dw soil (95 % confidence interval is 21-65 mg/kg soil dw).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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