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Diss Factsheets
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EC number: 205-359-9 | CAS number: 139-40-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- january 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Contains sufficient detail to suggest GLP-like characteristics even though no statement of certification is reported (reasonably thorough description of authors, dates, design, results, and interpretation).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: "apprisal of the safety of chemicals in foods, drugs and cosmetics (1959), the US Association of food and drug officials (AFDO).
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Propazine
- EC Number:
- 205-359-9
- EC Name:
- Propazine
- Cas Number:
- 139-40-2
- Molecular formula:
- C9H16ClN5
- IUPAC Name:
- 6-chloro-N2,N4-bis(propan-2-yl)-1,3,5-triazine-2,4-diamine
- Details on test material:
- Product designation: propazine
batch No. 368
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- The test was performed on 3 male and 3 female rabbits of the Himalayan breed weighing 1.5 to 2 kg. They were housed individually in metal cages, were kept at a constant room temperature of 18 ± 1°C, at a relative humidity of 55 ± 5 % and on a 14 hours light cycle day. The animals received ad libitum standard rabbit food NAFAG, Gossau SG and water.
Prior to treatment they were adapted to our laboratories for a minimum of 8 days
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- For treatment gauze patches of 2 5 x 2.5 cm with test material were applied to the prepared abraded and non abraded skin, in quantities of 0 1 g.
- Duration of treatment / exposure:
- 72 hours
- Observation period:
- 24 and 72 hours after the application.
- Number of animals:
- 3 male and 3 female
- Details on study design:
- Two days before treatment the entire back and the flank of the rabbits were shaved with an electric clipper and immediately before treatment the shaven skin on the left side was slightly scarified.
For treatment gauze patches of 2 5 x 2.5 cm with test material were applied to the prepared abraded and non abraded skin, in quantities of 0 1 g.
The patches were covered with an impermeable material and were fastened to the body of the rabbit with adhesive tape. The dressings were removed after a 24 hour exposure.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 72 hours after the treatment
- Score:
- 0.1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- The test material caused therefore a mild skin irritation to rabbits.
- Other effects:
- none
Any other information on results incl. tables
The primary irritation index is the moan value of the sum of the scores for erythema and edema from all 6 rabbits 24 and 72 hours after initiation of treatment.
The severity of skin irritation was rated as follows:
- mean value of less than 2 indicated mild
- from 2 to 6 moderate
- above 6 severe skin irritation
Applicant's summary and conclusion
- Interpretation of results:
- other: mild skin irritating to rabbits.
- Remarks:
- Criteria used for interpretation of results: not specified
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