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Diss Factsheets
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EC number: 202-874-0 | CAS number: 100-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
In a valid study performed according to international ISO guideline 9439 close to OECD 301B (reliability category 2) the test item cyclohexanone oxime was assessed to be readily biodegradable meeting the 10-day window requirement. Validity criteria of the guidelines were fulfilled. Based on CO2 evolution, within 28 days a mean degradation (2 replicates) of 79% was reached.
This is supported by a test on inherent biodegradability (Zahn-Wellens test) performed according to EU method C.9 (equivalent to OECD 302B; reliability category 2). Cyclohexanone oxime was assessed to be inherently biodegradable, fulfilling specific criteria.
Due to these results, further higher-tier simulation tests and a test on hydrolysis as a function of pH were neither regarded to be necessary nor exptected to yield further relevant information and therefore were not performed.
Due to a low experimentally determined log Kow of 1.256 (at 25 deg C) the potential for bioconcentration / bioaccumulation can be assumed to be very low. According to "column 2" in Annex IX of REGULATION (EC) No 1907/2006 testing is not required under these circumstances and experimental data are not available for this endpoint.
Out of the same reasons (low log Kow) also potential for adsorption can be assumed to be low. According to "column 2" in Annex VIII and IX of REGULATION (EC) No 1907/2006 no testing is required under these circumstances (log Kow < 3.0). Calculated Koc-values using KOCWIN v. 2.00 within US-EPA´s EPI Suite software package v. 4.11 were the following:
Based on exp. determined log Kow (1.265 at 25°C): 12.52 L/kg;
Based on MCI-method: 446.1 L/kg.
Thus, also based on these calculated values, adsorption potential for cyclohexanone oxime is low. This is further supported by the 3 -hours value from the reliable (with restrictions, RL2) Zahn-Wellens test, where adsorption was determined to be negligible.
The value based on the MCI-method will be used for chemical safety assessment, as accuracy of the MCI-method proved to be slightly better than the one based on log Kow.
In conclusion, cyclohexanone oxime is expected to partition preferentially to the aquatic phase where it will be rapidly and ultimately biodegraded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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