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EC number: 608-929-9
CAS number: 33955-44-1
- Standard Plate Test
- Preincubation Test
*see above for details
The test substance was tested for its mutagenic potential based on the
ability to induce point mutations in selected loci of several bacterial
strains in a reverse mutation assay. The tester strains (TA 1535, TA
100, TA 1537, TA 98 and E. coli WP2 uvrA) were tested in a standard
plate test (SPT) and preincubation test (PIT) both with and without
metabolic activation (Aroclor-induced rat liver S-9 mix). The dose range
used was 21 - 5250 µg/plate in both assays. Precipitation of the
test substance was found from about 525 µg/plate onward. A weak
bacteriotoxic effect was occasionally observed depending on the strain
and test conditions from about 2,625 µg/plate onward. An increase
in the number of his+ or trp+ revertants was not observed in the
standard plate test or in the preincubation test either without S-9 mix
or after the addition of a metabolizing system. According to the results
of the present study, the test substance is not mutagenic in the
Salmonella typhimurium/Escherichia ccli reverse mutation assay under the
experimental conditions chosen here.
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