Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: assessment of toxicokinetic behavior
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The information of this endpoint has been provided by ECHA as a result of an inquiry, thus the full access to data in the report is not accessible to the registrant. However the reliability is estimated to be at level 1: Study conducted in accordance with generally accepted scientific principles. Possible deficiencies do not affect the quality of relevant results.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
No information
Year:
1993
Bibliographic source:
Information provided by ECHA
Report Date:
1993

Materials and methods

Objective of study:
other: Assessment of toxicokinetic behaviour
Test guideline
Qualifier:
no guideline followed

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Orally administered test substance will hydrolyse in stomach to sorbitol and 3,4-dimethylbenzaldehyde. In humans, sorbitol is slowly absorbed. At least 75 % is metabolised to carbon dioxide and less than 3 % excreted in urine. In rats sorbitol can also be oxidized to glucose. 3,4-dimethylbenzaldehyde are expected to be oxidized to aromatic acid, which will be conjucated wiht glycine and excreted rapidly to urine.

Inhaled materials will behave like inert particulates, and are cleared from the lungs by mucociliary system.
Executive summary:

Orally administered test substance will hydrolyse in stomach to sorbitol and 3,4-dimethylbenzaldehyde. In humans, sorbitol is slowly absorbed. At least 75 % is metabolised to carbon dioxide and less than 3 % excreted in urine. In rats sorbitol can also be oxidized to glucose. 3,4-dimethylbenzaldehyde are expected to be oxidized to aromatic acid, which will be conjucated with glycine and excreted rapidly to urine.

Inhaled materials will behave like inert particulates, and are cleared from the lungs by mucociliary system.