Propan-2-ol

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study without detailed documentation.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

reliability scoring based on 2001 guideline for Test No. 423

Deviations:

yes

Remarks:

Lacking detail in methodology and results

GLP compliance:

no

Remarks:

Study pre-dates GLP

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

Sherman

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: Not reported
- Fasting period before study: Not reported
- Housing:Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum):Not reported
- Acclimation period:Not reported


ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):Not reported


IN-LIFE DATES: Not reported

Route of administration:

oral: unspecified

Vehicle:

acetone

Details on oral exposure:

No information

Doses:

Not reported. The authors state rats are given dosages differeing in a ratio of 10.

No. of animals per sex per dose:

6 rats/dose group

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days (or other?); Not reported
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: Not reported
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Not reported

Statistics:

Not reported

Preliminary study:

N/A

Sex:

not specified

Dose descriptor:

LD50

Effect level:

5 840 mg/kg bw

Mortality:

Not reported

Clinical signs:

other: Not reported

Gross pathology:

Not reported

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. accordingly these results are deemed reliable.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

5 840 mg/kg bw

Quality of whole database:

acceptable