Registration Dossier
Registration Dossier
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EC number: 445-910-2 | CAS number: 1388152-30-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in 2003 according to Method A6 of the Commission Directive 92/69/EEC and in accordance with GLP. Study material is well characterized.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Directive 92/69/EEC, A6 (flask method).
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- -
- EC Number:
- 445-910-2
- EC Name:
- -
- Cas Number:
- 1388152-30-4
- Molecular formula:
- Hill formula: C24 H32 N2 O7 Si CAS formula: C15 H20 O3 Si . C9 H12 N2 O4
- IUPAC Name:
- (1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 11.2 mg/L
- Temp.:
- 20 °C
- pH:
- 6.1
- Details on results:
- The solubility of the two dissociated components (i.e. acid component and the amine component) in water was determined to be 11.2 g/l each. Hence, water solubility of the whole substance is 11.2 g/l.
Any other information on results incl. tables
Results for Acid Component
| Sample Number | Time Shaken at ~30oC (hours) | Time Equilibrated at 20oC (hours) | Concentration (g/l) | Solution pH |
| 1 | 24 | 24 | 10.8 | 6.1 |
| 2 | 48 | 24 | 11.0 | 6.1 |
| 3 | 72 | 24 | 11.8 | 6.1 |
Mean concentration: 11.2g/l at 20.0 + 0.5 oC
Range: 10.8 to 11.8 g/l
Results for Amine Component
| Sample Number | Time Shaken at ~30oC (hours) | Time Equilibrated at 20oC (hours) | Concentration (g/l) | Solution pH |
| 1 | 24 | 24 | 10.9 | 6.1 |
| 2 | 48 | 24 | 11.0 | 6.1 |
| 3 | 72 | 24 | 11.8 | 6.1 |
Mean concentration: 11.2g/l at 20.0 + 0.5 oC
Range: 10.9 to 11.8 g/l
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The solubility of the two dissociated components (i.e. acid component and the amine component) in water was determined to be 11.2 g/l each. Hence, water solubility of the whole substance is 11.2 g/l. - Executive summary:
The substance has been shown to be very soluble in water.
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