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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin and eye irritation studies have been conducted on C4 Alcohol.  The results of the studies are: 
Eye Irritation: Non-irritating when tested according to OECD 405.
Skin Irritation: Non-irritating when tested according to OECD 404.

Key value for chemical safety assessment

Additional information

An acute eye irritation/corrosion study was done in three New Zealand White albino rabbits (according to OECD 405 and EC Council Directive 67/548/EEC). 62.1 mg of the test substance was instilled in the conjunctival sac of one of the eyes and then washed (24 hours later) with a solution of 2% fluorescein in water) to observe corneal epithelial damage, Eyes of the animals were examined approximately 1, 24, 48, 72 hours and 7 days after the instillation of the test substance. The irritation scores and description of local effects were recorded. All iridial irritation (grade 1 at 1 hour) resolved within 24 hours. Conjunctival irritation causes redness, chemosis and discharged and had completely resolved within 7 days in all animals. No corrosion, staining of ocular tissues, systemic toxicity or mortality were based during the test period. Therefore, the test article does not have to be classified and has no obligatory labelling requirements for eye irritation. 

 

A primary skin irritation/corrosion study was performed with the test article according to OECD Study Guideline no. 404 (2002). Three New Zealand White albino male rabbits were exposed to 0.5 grams (slightly moistened) of the test article by application onto clipped skin using a semi-occlusive dressing. The exposure period lasted for 4 hours, and then skin reactions were assessed at 1, 24,48 and 72 hours after exposure. Irritation scores of zero were given to all animals (no erythema or oedema were formed). No evidence of a corrosive effects, coloration, systemic toxicity or mortality were observed at any time during the observation period. Therefore, the test article does not have to be classified and has no obligatory labeling requirements for skin irritation based on the EC Criteria.

Justification for classification or non-classification

Criteria for classifying as a skin or eye irritant are not met.