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Long-term toxicity to aquatic invertebrates

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Key value for chemical safety assessment

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Focusing on environmental effects assessment, long term data obtained for chronic ecotoxicity of the formulation (fenoxaprop-P-ethyl + AE F122006)were used as read across for aquatic invertebrates. The tested concentrations of formulated test substance were 0.19, 0.38, 0.75, 1.5, and 3.0 mg/L. The nominal concentrations of the active ingredient fenoxaprop-P-ethyl (6.95% w/w) were 0.013, 0.026, 0.052, 0.10, and 0.21 mg/L and the nominal concentrations of the safener AE F122006 (7.30% w/w) were 0.014, 0.028, 0.055, 0.11, and 0.22 mg/L.


In a static renewal exposure for 21 days, fenoxaprop-P-ethyl + AE F122006 emulsifiable concentrate has chronic effects on the growth of the water flea, D. magna,at a concentration of 0.75 mg/L, but no effects were observed at a concentration of 0.38 mg/L. No safener (AE F122006) was found in the dilution water or control samples. The mean measured AE F122006 concentrations in the treated study samples (fresh solutions) were 0.01, 0.02, 0.04, 0.1, and 0.2 mg/L which represents a range of 75 to 91% of the nominal concentrations. No AE F122006 was found in the 72 hour old solutions.


As the test compound consists of one active ingredient, a safener, and formulation additives, degradation or adsorption behavior of the active ingredient is not necessarily indicative of the behavior of the other ingredients. Since the toxicity cannot be unequivocally attributed to only the measured active ingredient or safener, no adjustment of results for measured concentrations was made. Therefore, all toxicity values were calculated based on the nominal concentrations of the fenoxaprop-P-ethyl + AE F122006 emulsifiable concentrate added to the test water.

Using these values in the risk assessment represents a worst case situationfor the risk assessment of the safener and is sufficiently adequate for a conservative risk assessment. Therefore as a reasonable worst-case approach, the lowest long term NOEC is 0.38 mg/L.