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EC number: 956-606-9 | CAS number: 1373821-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
OECD Guideline 211, GLP, key study, validity 2:
21d-EC10 reproduction (Daphnia magna) : 1 mg/L based on measured (geom.mean)
21d-EC50 reproduction (Daphnia magna) : 2.3 mg/L based on measured (geom.mean)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC10
- Effect concentration:
- 1 mg/L
Additional information
To assess the long-term toxicity of the registered substance to aquatic invertebrates, one experimental key study is available.
The chronic toxicity of the test item to Daphnia magna was conducted according to OECD 211 and EU Method C.20, "Daphnia magna Reproduction Test" and EPA OPPTS 850.1300 (Daphnid Chronic Toxicity Test).
A preliminary media preparation trial indicated that a dissolved test item concentration of approximately 27.4 mg/L was obtained from a saturated solution method of preparation indicating this to be the limit of water solubility of this test item under test conditions. Based on the results of a preliminary range-finding test and an initial experiment, Daphnia magna were exposed (10 replicates of a single daphnid per group) to solutions of the test item at nominal concentrations of 0.5, 1.0, 2.0, 4.0 and 8.0% v/v saturated solution for a period of 21 days. The test solutions were renewed 3 times per week throughout the test. The test item solutions were prepared by stirring an excess (100 mg/L) of test item in test water using a propeller stirrer at approximately 1500 rpm for 24 hours. After the stirring period any undissolved test item was removed by filtration (0.2 um Sartorious Sartopore filter, first approximate 1 liter discarded in order to pre-condition the filter) to produce a 100% v/v saturated solution of the test item. This saturated solution was then further diluted as necessary, to provide the required test groups. The numbers of live and dead adult daphnia and young daphnids (live and dead) were determined daily. The daphnia were fed daily with a mixture of algal suspension and Tetramin®flake food suspension.
Analysis of the fresh test preparations on days 0, 5, 9, 14 and 19 showed measured test concentrations to range from 0.20 to 3.4 mg/L. With the exception of the 0.50% v/v saturated solution on Day 14/16 where a recovery of 72% (old versus fresh) was observed, there was no significant change in the measured concentrations of the aged test preparations on days 2, 7, 12, 16 and 21 and so the results are based on mean measured test concentrations only. Exposure of Daphnia magna to the test item gave the following results based on the mean measured test concentrations:
Endpoint (Reproduction) | |
EC10(95% confidence limits) | 1.0 (n.d) |
EC50(95% confidence limits) | 2.3 (n.d) |
n.d - None determined due to the nature of the data.
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