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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case report
- Adequacy of study:
- supporting study
- Study period:
- n.a.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: case report
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- 7758-99-8
- Cas Number:
- 7758-99-8
- IUPAC Name:
- 7758-99-8
- Reference substance name:
- copper sulfate pentahydrate
- IUPAC Name:
- copper sulfate pentahydrate
- Details on test material:
- ingestination of 8 g copper sulfate pentahydrate in suicida attempt
Constituent 1
Constituent 2
Method
- Subjects:
- n.a. emergency in hospital
- Route of exposure:
- oral
- Reason of exposure:
- other: suicida attempt
- Exposure assessment:
- estimated
Results and discussion
- Clinical signs:
- He was lethargic and vomiting spontaneously. Blue staining of the oral mucosaand vomitus on his clothes were
noticed. The temperature was 36.2°C, the pulse rate was 92, the respirations were 30, and the blood pressure was 160/64
mmHg.Noneurological focal sign was present on examinations. The laboratory data revealed hemoconcentration with
18.7 g/dl of hemoglobin and 55% of hematocrit. Although indirect bilirubin was 1.4 mg/dl, other renal and liver function
tests remained in the normal limit.
Applicant's summary and conclusion
- Conclusions:
- Ingested copper induces mucous irritation, nausea, vomiting and diarrhea.
Ionizied copper is rapidly absorbed from the stomach and the intestine, and the serum copper level increases rapidly. The element
is bound to alabumin and ceruloplasmin, and is taken up by the liver, kidney, lungs and red blood cells. Hemeolytic anemia and
renal tubular neucrosis may followed by 36-48 hours after exposure. The primary route of excretion is thourgh bile and feces.
The toxicity of copper at a cellular level is probably related to the sulfhyryl moieties of glucose-6-phosphtate dehydrogenase
and glutathione, thereby reducing their free radical scavenging activities. Copper
induces hemolysis through oxidation of hemoglobin sulfhydryl groups. Copper also inhibits Na+/K(+)-ATPase and increases
the permeability of cell membrane. Since copper is known to damage human skeletal muscle cells, copper intoxication
could cause rhabdomyolysis. Althougha case of copper-induced acute rhabdomyolysis in Wilson's disease was
reported , rhabdomyolysis in acute copper intoxication has been rarely reported . This might be because myoglobinuria
might be overlooked by the coexistence of hemoglobinuria secondary to hemolytic anemia.
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