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EC number: -
CAS number: -
The test substance is a UVCB substance with an overall high water
solubility (305 mg/L)/ The log Pow of the majority of its constituents
is very high (94.24% with log Pow > 4, 67.0% with log Pow > 10.) A
toxicant can enter the body via the gastrointestinal tract, the lungs
and the skin. In general, a substance needs to be dissolved before it
can be taken up from the gastrointestinal tract after oral
administration. The test substance is a liquid with a moderate to high
water solubility (305 mg/L) and can therefore dissolve into GI fluids
and hence make contact with the mucosal surface. Furthermore, as the
substance is surface active, the absorption can be enhanced if the
substance undergoes micellar sobulization or by bile salts. There, for
risk assessment purposes oral obsorption of the test substance is set at
For Inhaled substances the process of deposition of the substance on the
surface of the respiratory tracr and the actual absorption have to be
differentiated. The vapour pressure for the test substance is low (0.036
Pa at 20C), indicating a low volatility. It is not likely that the test
substance will rach the nasopharyngeal region or subsequently the
tracheo/bronchial/pulmonary region via inhaltion of vapour.
The test substance is a liquid which can potentially be taken up across
the skin. According to the criteria given in the REACH Guidance, a
default value of 100% dermal absorption should be used unless MW > 500
and log Pow <-1 or > 4, in which case a value of 10% skin absorption
should be chosen. These criteria are fulfilled for the majority of
constituents of the test substance (94.2% with log Pow >4, MW of all
constituents > 500 g/mol.) The substance was not irritating to skin
inthe available skin irritation study, but signs of dermal irritation
were noted in the available acute dermal toxicity study.
Once absorbed, the substance can be distributed throughout the body,
based on irs moderate to high water solubility (305 g/L). Considering
very high low Pow of the majority of the constituents, the test
substance is expected to accumulate in adipose tissue. Metabolism of the
substance is epected to involve oxidative desulfuration, ester
hydrolysis, aliphatic C-oxidation, and phosphate ester hydrolysis. The
parent substance is expected to be completley metabolised..
Biliary and foecal excretion may be expected to occur based on the
molecular weight of the substance (as well as several of the
metabolites) and its high apolarity. Based on moderate to high water
solubility, some degree of urinary excretion cannot be excluded for the
test substance as well as its metabolites although the high molecular
weight of the parent substance may limit urinary excretion.
Based on the physical/chemical properties of the substance, absorption
factors for this substance are derived to be 100% oral, 100% inhalation
and 10% dermal for risk assessment purposes. Based on the metabolism
model, the parent is expected to be completley metabolized, but there
are several stable metabolites. Fecal and urinary excretion are expected
based on the molecular weight and water solubility of the substance and
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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