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Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2006

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-dimethyloctadecylamine N-oxide
EC Number:
219-919-5
EC Name:
N,N-dimethyloctadecylamine N-oxide
Cas Number:
2571-88-2
Molecular formula:
C20H43NO
IUPAC Name:
N,N-dimethyloctadecanamine oxide
Test material form:
liquid
Details on test material:
Test material is skin lotions containing 2.5% C18 DMAO.
Other ingredients were: 35% of either mineral oil or isopropyl palmitate, 1% cetyl alcohol, 1% lanolin, with or without 0.2% quaternary preservative (50:50 mixture of alkyl dimethyl benzyl ammonium chloride and alkyl dimethyl ethylbenzyl ammonium chloride); the balance was water

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: skin lotion
Controls:
not specified
Amount / concentration applied:
Not specified
Duration of treatment / exposure:
Not specified
Observation period (in vivo):
Not specified
Number of animals or in vitro replicates:
1-3
Details on study design:
For rabbits with washed eye treatment, washing occurred 4 seconds after application

Results and discussion

In vivo

Resultsopen allclose all
Remarks on result:
no indication of irritation
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritant / corrosive response data:
No irritation was observed in rabbits with washed or unwashed eyes

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) was evaluated for eye irritation in the rabbit according to the Draize method. Four skin lotions containing 2.5% C18 Amine Oxide were tested and shown to be non irritating.
Executive summary:

N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) was evaluated for eye irritation in the rabbit according to the Draize method. Four skin lotions containing 2.5% C18 Amine Oxide were tested and shown to be non irritating.