Registration Dossier
Registration Dossier
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EC number: 255-679-8 | CAS number: 42142-52-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro, other
- Remarks:
- QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Derek Nexus 6.0
- Year:
- 2 017
- Bibliographic source:
- Derek Nexus is an expert knowledge-based software.
Materials and methods
- Principles of method if other than guideline:
- - Software tool(s) used including version:
Derek Nexus 6.0
- Model(s) used: or Windows - Mutagenicity
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' and/or 'Cross-reference' - GLP compliance:
- no
Test material
- Reference substance name:
- α-[2-(methylamino)ethyl]benzyl alcohol
- EC Number:
- 255-679-8
- EC Name:
- α-[2-(methylamino)ethyl]benzyl alcohol
- Cas Number:
- 42142-52-9
- Molecular formula:
- C10H15NO
- IUPAC Name:
- 3-(methylamino)-1-phenylpropan-1-ol
1
Results and discussion
Test results
- Genotoxicity:
- negative
- Remarks on result:
- other: prediction
Applicant's summary and conclusion
- Conclusions:
- 3-(Methylamino)-1-phenylpropan-1-ol does not satisfy the CLP criteria for mutagenicity classification.
The substance falls within the applicability domain described above and therefore, the predicted value can be considered reliable.
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