(3AS,4S,6AR)-4-METHOXYTETRAHYDROFURO[3,4- B]FURAN-2(3H)-ONE

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07-12 October 2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

- Batch n°: 00467090 (charge 05C0836)
- Expiration date: 04 May 2006
- Purity: 99.9%
- Storage condition of test material: at room temperature at about 20°C

Key result

Boiling pt.:

>= 280.9 - <= 295.8 °C

Atm. press.:

99.9 kPa

Preliminary test

An endothermic heat effect, the boiling, was detected starting at 281.3°C. After the experiment, the sample had lost about 99.6% of its mass, was molten and brownish in color.

Main test

DSC-runs were recorded between 230°C and 320°C with a heating rate of 5 K/min. In the first main test run, the boiling range was determined to be between 282.1°C and 293.8°C and in the second main test run between 279.8°C and 297.8°C. During these runs, the samples lost about 99.9% and 99.3% of their mass, respectively. After the measurement the sample cube was empty. Only a small brown ring remained.

Conclusions:

The boiling range of TIC2782 (T002907) was determined to be between 280.9°C and 295.8°C (554.1 K and 569.0 K) using DSC.

Description of key information

A GLP study was performed according to OECD guideline 103 and EU Method A.2 without deviations (Weissenfeld M, 2006) . The boiling range of T002907 was determined to be between 280.9°C and 295.8°C (554.1 K and 569.0 K) using DSC.